冠心病心绞痛中医证候分布与白细胞介素-6、内皮素-1相关性研究

目的探讨冠心病心绞痛中医证候分布规律及其与白细胞介素-6（IL-6）、内皮素（ET-1）的关系，为中医辨证客观化提供依据。方法对100例经冠状动脉造影诊断为冠心病心绞痛患者参照一定的标准进行证候要素提取，并测定IL-6、ET-1水平，作相关性分析。结果证型分布以本虚标实证居多；证候分布中气虚、痰浊、血瘀三型所占比例较大，关系为血瘀〉痰浊〉气虚；实证较虚实夹杂证IL-6水平明显升高（P〈0.05）；夹痰夹瘀证较夹痰证和夹瘀证ET-1水平明显升高（P〈0.05）。结论冠心病心绞痛中医证型以本虚标实证居多，冠心病心绞痛的基本证候是血瘀、痰浊、气虚；IL-6、ET-1与中医证型分布具有相关性，两者均能作为辨证的客观参考依据。

Correlation Research of Syndromes Distribution of Chinese Medicine with IL-6 and ET-1 in Angina Pectoris of Coronary Heard Disease

Objective To discuss the correlation of syndrome distribution of Chinese medicine with interleukin-6（IL-6） and endothelin-1（ET-1） in angina pectoris of coronary heart disease so as to provide the evidence for the objectivity of syndrome differentiation in Chinese medicine. Methods In reference to a certain standard, the elements of syndrome were collected among 100 cases of angina pectoris of coronary heart disease diagnosed by coronary angiography and the levels of LI-6 and ET-1 were measured for correlation analysis. Results Most syndromes indicated the deficiency of the root and the excess of symptoms, of which, the syndromes of qi deficiency, stagnation of phlegm and blood stasis occupied the large proportions. The relation of their proportions was blood stasis 〉 stagnation of phlegm 〉 qi deficiency. Compared with mixed syndrome of excess and deficiency, IL - 6 level increased apparently in excess syndrome （P〈0.05）. Compared with the syndrome of either phlegm or stasis, ET - 1 level increased apparently in the syndrome with mixture of phlegm and stasis （P〈0.05）. Conclusion Angina pectoris of coronary heart disease indicates mostly the deficiency of the root and the excess of symptoms according to the differentiation in Chinese medicine. The basic syndromes of the disease include blood stasis, stagnation of phlegm and qi deficiency. IL - 6 and ET - 1 are correlated with the syndrome distribution in Chinese medicine and they can be taken as the objective reference evidences for syndrome differentiation of Chinese medicine.