| 不同雄激素水平PCOS患者诱导排卵临床结局分析 |
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| 引用本文： | 郭丽娜,张君,吕翠婷,赵素英,乜照燕,张娜,甄秀丽.不同雄激素水平PCOS患者诱导排卵临床结局分析[J].现代妇产科进展,2011,20(12):952-954. |
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| 作者姓名： | 郭丽娜 张君 吕翠婷 赵素英 乜照燕 张娜 甄秀丽 |
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| 作者单位： | 1. 河北医科大学第四医院,石家庄,050011
2. 河北省赞皇县医院 |
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| 摘 要： | 目的:探讨多囊卵巢综合征(PCOS)患者在不同雄激素水平下诱导排卵的临床妊娠结局。方法:PCOS合并不孕患者352例,根据诱导排卵前基础睾酮(T)水平分为4组:A组60例,基础T正常,直接诱导排卵;B组64例,基础T正常,但仍给予达英-35治疗3个周期后诱导排卵;C组120例,基础T升高,给予达英-35治疗3个周期,复查T正常后诱导排卵;D组108例,基础T升高,给予达英-35治疗3个周期,复查T仍高于正常水平,经患者知情同意后,诱导排卵。比较4组子宫内膜厚度、尿促性素(HMG)用量、周期排卵率、临床妊娠率、流产率的差异。结果:4组子宫内膜厚度、排卵周期临床妊娠率组间比较差异无统计学意义(P>0.05);A组HMG用量最多,周期排卵率、总临床妊娠率最低,与其它3组的差异均有统计学意义(P<0.01,P<0.01,P<0.05);B、C、D组间周期排卵率、总妊娠率比较差异无统计学意义(P>0.05)。A组早期流产率最高,但4组间比较差异无统计学意义(P>0.05)。结论:基础T水平正常的PCOS患者,诱导排卵前应用口服避孕药治疗可改善临床妊娠结局;口服避孕药治疗后T未降至正常水平,且有生育要求的PCOS患者可试行诱导排卵治疗。
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| 关 键 词： | 多囊卵巢综合征 不孕 高雄激素血症 诱导排卵 临床妊娠率 |
Analysis of clinical outcomes of ovulation induction in PCOS patients with different androgen levels |
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| Affiliation: | Guo Lina1,Zhang Jun2,Lü Cuiting1,et al.1.The Fourth Hospital of Hebei Medical University,Shijiazhuang 050011,2.Zanhuangxian Hospital in Hebei Province |
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| Abstract: | Objective:To investigate the clinical pregnancy outcomes of induced ovulation in PCOS patients with different androgen levels.Methods:352 PCOS patients with infertility were divided into 4 groups according to testosterone(T)level before induced ovulation:group A of 60 patients whose basal T were normal to directly induce ovulation;group B of 64 patients whose basal T were normal too were induced ovulation after 3 cycles of Diane-35 treatment;group C of 120 patients whose basal T were increased,after 3 cycle... |
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| Keywords: | Polycystic ovary syndrome Infertility Hyperandrogenism Induced ovulation Clinical pregnancy rate |
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