| 综合影像学评价中华小型猪慢性心肌缺血 |
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| 引用本文： | 唐翔,吕滨,赵世华,唐跃,吕凤英,方纬,陆敏杰,鲁锦国,陈雄彪,蒋世良.综合影像学评价中华小型猪慢性心肌缺血[J].中国医学影像技术,2010,26(3):421-424. |
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| 作者姓名： | 唐翔 吕滨 赵世华 唐跃 吕凤英 方纬 陆敏杰 鲁锦国 陈雄彪 蒋世良 |
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| 作者单位： | 中国医学科学院,北京协和医学院,阜外心血管病医院放射科,北京,100037 |
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| 基金项目： | 教育部新世纪优秀人才支持计划 |
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| 摘 要： | 目的 评价多排探测器螺旋CT(MDCT)、磁共振成像(MRI)、单光子发射型体层摄影术(SPECT)对中华小型猪慢性心肌缺血模型的显示效果.方法 中华小型猪6只,接受MDCT扫描1次后,在前降支近段放置Ameroid环,当日行MDCT、MRI扫描.术后第2、27天再次行SPECT,28天完成冠状动脉造影(CAG)、MDCT、MRI,最后处死动物行病理检查.结果 2只实验猪饲养中死亡,4只完成实验.病理显示3只实验猪有心内膜下梗死,1只无梗死.CAG显示3只实验猪狭窄>50%.MDCT的动脉期减低区域、MRI的首过减低区域以及SPECT的减低区域均与TTC染色显示的梗死区域一致.MDCT测得术后28天的ESV高于术前与术后当日(P<0.05),其余指标差异均无统计学意义.MRI测得EDV术后28天高于术后当日(P<0.001),其余各指标差异均无统计学意义.MDCT测得的SV、EDV均值均高于MRI(P均<0.05);二者测得的ESV与EF差异无统计学意义(P均>0.05).术前、术后当日、术后28天左心室前壁动脉期CT值差异有统计学意义(F=10.274,P=0.011).结论 MDCT动脉期、MRI首过灌注、SPECT显示的左心室前壁灌注减低与TTC染色梗死心肌相对应.心肌缺血后CT值减低.
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| 关 键 词： | 体层摄影术 螺旋计算机 磁共振成像 体层摄影术 发射型计算机 单光子 猪 雏型 心肌缺血 |
| 收稿时间： | 8/4/2009 12:00:00 AM |
| 修稿时间： | 2009/11/15 0:00:00 |
Integrated imaging evaluation of chronic myocardial ischemia in Chinese mini-swine model |
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| TANG Xiang,LV Bin,ZHAO Shi-hu,TANG Yue,LV Feng-ying,FANG Wei,LU Min-jie,LU Jin-guo,CHEN Xiong-biao and JIANG Shi-liang.Integrated imaging evaluation of chronic myocardial ischemia in Chinese mini-swine model[J].Chinese Journal of Medical Imaging Technology,2010,26(3):421-424. |
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| Authors: | TANG Xiang LV Bin ZHAO Shi-hu TANG Yue LV Feng-ying FANG Wei LU Min-jie LU Jin-guo CHEN Xiong-biao and JIANG Shi-liang |
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| Affiliation: | Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China;Department of Radiology, Fuwai Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100037, China |
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| Abstract: | Objective To assess multi-detector CT(MDCT),MR and single photon emission computed tomography(SPECT) in detection of chronic myocardial ischemia in Chinese mini-swine models.Methods Six male pigs received MDCT scan firstly.Then Ameroid narrow ring was placed in the left descending branch and MDCT,MR were performed at the same day.On the 2nd,27th day,SPECT was given.Coronary angiography(CAG) was given on the 28th day,and then MDCT and MRI.The animals were killed after allexaminations.The pathological examina... |
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| Keywords: | Tomography spiral computed Magnetic resonance imaging Tomography emission-computed single-photon Swine miniature Myocardial ischemia |
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