| 基因转移与肿瘤基因工程疫苗 |
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| 引用本文： | 付体辉,谢之荣.基因转移与肿瘤基因工程疫苗[J].生物化学与生物物理进展,1995,22(1):26-30. |
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| 作者姓名： | 付体辉 谢之荣 |
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| 作者单位： | 四川省肿瘤研究所;四川省肿瘤研究所 |
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| 摘 要： | 综述了近年来有关利用基因转移技术修饰肿瘤细胞制备肿瘤基因工程疫苗的最新研究进展，着重阐述了逆转录病毒载体介导的基因转移及其安全性；归纳了目前可用于肿瘤基因工程疫苗的各种目的基因的特点及作用并对这类肿瘤疫苗制备过程中所存在的问题进行了分析.
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| 关 键 词： | 基因转移 逆转录病毒载体 免疫原性 肿瘤基因工程疫苗 |
| 收稿时间： | 1994/1/17 0:00:00 |
| 修稿时间： | 1994/4/27 0:00:00 |
Gene Transfer and Genetically-Engineered Tumor Cell Vaccine |
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| Fu Tihui and Xie Zhirong.Gene Transfer and Genetically-Engineered Tumor Cell Vaccine[J].Progress In Biochemistry and Biophysics,1995,22(1):26-30. |
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| Authors: | Fu Tihui and Xie Zhirong |
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| Affiliation: | Department of Biochemistry, Sichuan Cancer Institute;Department of Biochemistry, Sichuan Cancer Institute |
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| Abstract: | The newly developed technique of retroviral-mediated gene transfer(RMGT ) which mainly involves the transfecting efficiency and safety aspects of RMGT were discussed.And the characteristics and effects of some exogenous genes which could be used to modify the immunogenicity of tumor cells were also classified and presented.Finally,the problems existed both in RMGT and in the preparation of genetically-engineered tumor cell vaccine were analysed. |
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| Keywords: | gene transfer retroviral vector immunogenicity genetically-engineered tumor cell vaccine |
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