| 8-甲氧补骨脂素脂质体凝胶的皮肤渗透性研究 |
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| 引用本文： | 吴宏霞,何文,蔡鸿生,罗顺德,张先洲.8-甲氧补骨脂素脂质体凝胶的皮肤渗透性研究[J].中国药房,2003,14(11):655-657. |
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| 作者姓名： | 吴宏霞 何文 蔡鸿生 罗顺德 张先洲 |
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| 作者单位： | 武汉大学人民医院药学部,武汉市,430060 |
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| 基金项目： | 湖北省科技攻关计划项目 (2001AA301B06) |
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| 摘 要： | 目的 :研究8 -甲氧补骨脂素脂质体凝胶的皮肤渗透性。方法 :以凝胶与敏白灵酊为对照 ,将8 -甲氧补骨脂素脂质体凝胶应用于离体及在体大鼠皮肤 ,用反相高效液相色谱法测定接收介质、皮肤、血液及其它组织中8 -甲氧补骨脂素的含量。结果 :离体条件下 ,脂质体凝胶具有最小的透皮速率和最大的皮内滞留量 ;在体条件下 ,包封于脂质体中的药物在皮肤中滞留量分别是凝胶和酊剂的 (4 37±0 91)倍和 (3 36±0 58)倍。结论 :8 -甲氧补骨脂素脂质体凝胶具有显著的局部皮肤靶向性。
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| 关 键 词： | 8-甲氧补骨脂素 脂质体凝胶 渗透性 |
| 文章编号： | 1001-0408(2003)11-0655-03 |
| 修稿时间： | 2002年11月29 |
The Percutaneous Permeability of Methoxypsoralen Liposomal Gel |
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| WU Hongxia,HE Wen,CAI Hongsheng,LUO Shunde,ZHANG Xianzhou.The Percutaneous Permeability of Methoxypsoralen Liposomal Gel[J].China Pharmacy,2003,14(11):655-657. |
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| Authors: | WU Hongxia HE Wen CAI Hongsheng LUO Shunde ZHANG Xianzhou |
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| Abstract: | OBJECTIVE:To study the percutaneous permeability of methoxypsoralen liposomal gel METHODS:The preparations were applied on the rat skin in vitro and in vivo with common gel and Mingbailing tincture as control,and the drug concentrations in the receiver,skin,blood and other organs were determined by RP-HPLC RESULTS:In vitro experiment,liposomal gel showed the lowest percutaneous permeation rate and the highest retention in skin In vivo studies illuminated that the skin depositions of drug encapsulated in liposome was(4 37±0 91) and (3 36±0 58) times those of the common gel and tincture respectively CONCLUSION:Methoxypsoralen liposomal gel showed an evident targeting effect on skin |
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| Keywords: | methoxypsoralen liposomal gel permeability |
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