| 多灶性膀胱癌不同瘤体间p21、p53及EMA的表达 |
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| 引用本文： | 孙颖浩,颜克钧,王林辉,许传亮,戚晓升,钱松溪,马永江.多灶性膀胱癌不同瘤体间p21、p53及EMA的表达[J].中华泌尿外科杂志,2001,22(7):423-425. |
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| 作者姓名： | 孙颖浩 颜克钧 王林辉 许传亮 戚晓升 钱松溪 马永江 |
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| 作者单位： | 第二军医大学长海医院泌尿外科 |
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| 摘 要： | 目的：探讨多灶性膀胱癌的发生机制。方法：运用免疫组化法检测5例多灶性膀胱癌20个不同瘤体中p21,p53和EMA的表达，结果：5例患者中有4例散在肿瘤标本P21及P53表达一致，5例MEA表达一致。结论：多灶性膀胱癌可能为单克隆起源。
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| 关 键 词： | 多灶性膀胱肿瘤 p21基因 p53基因 EMA 肿瘤发生 |
| 修稿时间： | 2000年7月17日 |
The expressions of p21,p53 and EMA in various tumors of multifocal bladder cancers |
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| SUN Yinghao,YAN Kejun,WANG Linhui,et al..The expressions of p21,p53 and EMA in various tumors of multifocal bladder cancers[J].Chinese Journal of Urology,2001,22(7):423-425. |
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| Authors: | SUN Yinghao YAN Kejun WANG Linhui |
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| Affiliation: | SUN Yinghao,YAN Kejun,WANG Linhui,et al.Department of Urology,Changhai Hospital,the Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Objective To study the mechanism of occurrence of the multifocal bladder cancers. Methods The expressions of p21,p53 and EMA in twenty specimens from 5 cases of multifocal bladder cancers were studied by means of immunohistochemistry. Results In 4 of 5 cases, the expressions of p21 and p53 were correspondent in scattering specimens from the same patient. In all the 5 cases, the expressions of EMA were correspondent in scattering specimens from the same patient. Conclusions Multifocal bladder cancer may originate from the same monocolone. |
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| Keywords: | Bladder neoplasms Carcinoma Genes |
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