冠心病病人血清脂联素与可溶性细胞间黏附分子-1的变化及意义

目的：探讨冠状动脉粥样硬化性心脏病（CHD）病人血清中脂联素与可溶性细胞间黏附分子-1（sICAM-1）水平的变化及临床意义。方法：选择冠心病病人59例，其中急性冠脉综合征（ACS）31例，稳定性心绞痛（SAP）28例，采用ELISA法检测病人血清脂联素、sICAM-1的浓度并与20例健康对照比较。结果：ACS组病人血清脂联素的浓度显著低于SAP组和对照组（P〈0．05）．sICAM-1浓度显著高于SAP组和对照组（P〈0．05），血清脂联素的浓度与sICAM-1水平呈负相关（r=-0．295，P〈0．05）。结论：血清脂联素与sICAM-1水平的变化与冠脉病变的稳定性有关，检测血清中脂联素与slCAM-1对于冠心病的辅助诊断、病情判断、及预防治疗有重要临床意义。

Significance of DetectingSerum Levels of Adiponection and Soluble Intercellularadhesion Molecule-1 in Patients with Cornary Heart Disease

Objective： To investigate the clinical significance of variation of serum adiponectin in patients with coronary heart disease （CHD）. Methods： Serum adiponectin and slCAM-lwere measured by Enzyme-linked Immunosorbent Assay （ELISA） in59 patients with CHD, and compared with 20 healthy subjects. Results： Serum concentration of adiponectin in patients with AMI were significantly lower than in paitents with SAP and normals （P〈0.05）while Serum concentration of slCAM- 1 in patients with AMI were significantly elevated than in paitents with SAP and normals （P〈0.05）. adiponectin correlated negatively with slCAM-1 （r=-0.295,P〈0.05）. Conclusion： The variation of serum adiponectin and slCAM-lin patients with CHD reflect the stability of the atherosclerotic plaque. Detecting of serum adiponectin and slCAM-1 is great value to the diagnosis,treatment and progonosis of CHD.