| 间充质干细胞体外分化为多巴胺能神经元的研究进展 |
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| 引用本文： | 吕翠,王晓萃,付文玉.间充质干细胞体外分化为多巴胺能神经元的研究进展[J].生物磁学,2009(16):3194-3197. |
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| 作者姓名： | 吕翠 王晓萃 付文玉 |
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| 作者单位： | [1]潍坊医学院组织学与胚胎学教研室,山东潍坊261053 [2]潍坊医学院解剖学教研室,山东潍坊261053 |
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| 基金项目： | 基金项目：山东省自然科学基金（Y2003C01,Y2008C129）,山东省“泰山学者”建设工程专项经费,潍坊医学院博士启动基金 |
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| 摘 要： | 骨髓间充质干细胞（MSCs）有来源广泛、易于分离培养、不易引起免疫排斥等特点，使其成为细胞治疗和基因治疗的种子细胞，具有广泛的科研和临床应用价值。骨髓MSCs具有多向分化潜能，在特定条件下能诱导分化成神经元甚至是更为特异的多巴胺能神经元，为帕金森病进行细胞移植疗法提供了理想的细胞来源。本文就近年来体外诱导MSCs向多巴胺能神经元定向分化所涉及到的常用诱导因素和诱导方法及途径予以综述。
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| 关 键 词： | 间充质干细胞 多巴胺 分化 |
Advances on Mesenchymal Stem Cells Differentiation into Dopaminergic Neurons in Vitro |
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| LV Cui,WANG Xiao-cui,FU Wen-yu.Advances on Mesenchymal Stem Cells Differentiation into Dopaminergic Neurons in Vitro[J].Biomagnetism,2009(16):3194-3197. |
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| Authors: | LV Cui WANG Xiao-cui FU Wen-yu |
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| Affiliation: | 1 Department of Histology ＆ Embryology, Weifang Medical College, Weifang 261053, China; 2 Department of Anatomy, Weifang Medical College, Weifang 261053, China) |
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| Abstract: | Bone marrow mesenchymal stem cells（MSCs） are characterized by wide source, easy isolation and culture and no immunologic rejection.With wide scientific research and clinical application, MSCs have been regarded as seed cells for cell therapy and gene therapy. With multi-directional differentiation potential, bone marrow MSCs can differentiate into dopaminergicneurons in definite condition. They are considered as ideal seed cells in autologous transplantation in patients with Parkinson＇s disease（PD）. This article summarized how to induce MSCs to differentiate into dopaminergic neurons in vitro. |
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| Keywords: | Mesenchymal stem cells Dopamine Differentiation |
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