| 3-氯-4-甲基哒嗪的合成研究 |
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| 引用本文： | 阮婧华,杨绍娟.3-氯-4-甲基哒嗪的合成研究[J].广州化工,2012,40(15):79-80. |
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| 作者姓名： | 阮婧华 杨绍娟 |
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| 作者单位： | 1. 贵州省中国科学院天然产物化学重点实验室,贵州贵阳,550002
2. 南昌航空大学科技学院,江西南昌,330034 |
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| 基金项目： | 贵州省省长基金资助，贵州省创新能力建设资助 |
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| 摘 要： | 介绍了标题化合物的合成方法。以柠康酸酐和水合肼为起始原料,经环合、氯代、水合肼取代、脱肼基共4步反应合成了目标化合物,并经1HNMR等对其结构进行了表征。本合成反应条件温和、原料易得、操作简便,适合于工业化生产。反应总收率为30%。
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| 关 键 词： | 3-氯-4-甲基哒嗪 水合肼 柠康酸酐 合成 |
Research on the Synthesis of 3-chloro-4-methylpyridazine |
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| RUAN Jing-hua,YANG Shao-juan.Research on the Synthesis of 3-chloro-4-methylpyridazine[J].GuangZhou Chemical Industry and Technology,2012,40(15):79-80. |
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| Authors: | RUAN Jing-hua YANG Shao-juan |
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| Affiliation: | 1 The Key Laboratory of Chemistry for Natural Products of Chinese Academy of Sciences,Guizhou Guiyang 5500021;2 Polytechnic School of Nanchang Hangkong University,Jiangxi Nanchang 330034,China) |
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| Abstract: | The synthesis method of 3-chloro-4-methylpyridazine was introuced,which was an important intermediate of pesticides and anti-viral drugs.The synthesis was accomplished in four steps,with hydrazine hydrate and citraconic anhydride as the start raw materisls.And its structure was verified by 1HNMR.The total product yield was 30%.This program with mild reaction conditions,realily available materials,and easy operation,was suitable for industrial production. |
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| Keywords: | 3-chloro-4-methylpyridazine hydrazine hydrate citraconic anhydride synthesis |
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