| 药物相互作用动力学分析方法及其CoDrug软件 |
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| 引用本文： | 郑青山,孙瑞元.药物相互作用动力学分析方法及其CoDrug软件[J].中国临床药理学与治疗学,2002,7(1):81-82. |
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| 作者姓名： | 郑青山 孙瑞元 |
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| 作者单位： | 安徽省药物临床评价中心,皖南医学院弋矶山医院,芜湖,241001 |
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| 摘 要： | 在药物治疗学领域，复方新药的组方筛选和优化，临床联合用药方案的设计与评价，以及中药方剂配伍规律的定量研究，均需要药物相互作用的动力学分析。本结合其专用软件CoDrug，简介了多药物联合应用时优选最佳组份，剂量和比例的权重配方法；分析药物相互作用动态规律的参数法和映射法，以及多指标综合分析法，列出了系统研究药物相互作用动力学的完整方案。
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| 关 键 词： | 药物相互作用 药物治疗 药物协同作用 CoDrug软件 动力学分析法 |
| 文章编号： | 1009-2501(2002)01-0081-05 |
| 修稿时间： | 2002年2月5日 |
Methods in analysis of the dynamics of drug interaction and its software CoDrug |
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| ZHENG Qing,Shan,SUN Rui,Yuan.Methods in analysis of the dynamics of drug interaction and its software CoDrug[J].Chinese Journal of Clinical Pharmacology and Therapeutics,2002,7(1):81-82. |
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| Authors: | ZHENG Qing Shan SUN Rui Yuan |
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| Abstract: | In clinical and experimental therapeutics, the quantitative analysis of drug interaction will supply a tool for optimizing and evaluating a combination in the study of compound drug, the design of combination drug therapy, and the evaluation of traditional medicine formulae. This paper listed the systematic methods of the quantitative analysis, including the weighted modification method for optimizing constituents, doses and ratio in combination, the parameter method and the reflection method for dynamic analysis of drug interaction, and a comprehensive method for multiple response indexes. The software CoDrug about these methods also was introduced. |
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| Keywords: | drug interaction combination drug therapy drug synergism drug antagonism |
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