The effects of levodopa and haloperidol on flash and pattern ERGs and VEPs in normal humans |
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Authors: | Peter Bartel PhD Marie Blom Elna Robinson Cees Van Der Meyden Klerk De Sommers Pieter Becker |
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Affiliation: | (1) Department of Neurology, H.F. Verwoerd Hospital and University of Pretoria, Pretoria, South Africa;(2) Department of Pharmacology, University of Pretoria, Pretoria, South Africa;(3) Institute for Biostatistics, Medical Research Council, Pretoria, South Africa;(4) Department of Neurology, H.F. Verwoerd Hospital, P. Bag X 169, 0001 Pretoria, South Africa |
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Abstract: | We investigated the effects of single doses of the dopamine agonist levodopa and the dopamine antagonist haloperidol on pattern and flash electroretinograms (ERGs) and visual evoked potentials (VEPs) in normal subjects. A placebo and two treatment regimens were administered in a randomized double-masked design. No significant intertreatment differences in the pattern ERGs and VEPs were noted. Although not statistically significant, a clearly discernible tendency was found for increased flash ERG b-wave amplitudes after levodopa administration compared with placebo. In comparison with placebo and levodopa, haloperidol was associated with significantly prolonged flash ERG b-wave implicit times, including each oscillatory potential, which also showed increased duration, particularly in the O1–O3 interpeak implicit time. The failure of pattern ERGs and VEPs to show changes after haloperidol may have been related to the timing of the recordings, which took place during the presumed phase of rising blood levels and before the flash ERG and VEP recordings. Our findings further demonstrated the reliability of the flash ERG in revealing changes in dopaminergic status in the visual system and suggest that steady-state (flicker) ERGs, cone ERGs, and oscillatory potentials have particular use in this regard.Abbreviations C-ERG
Cone dominated ERG
- M-ERG
mixed rod and cone ERG
- R-ERG
rod dominated ERG
- S-ERG
steady-state (flicker) ERG
- OP
oscillatory potential
- P-ERG
pattern-reversal ERG
- F-VEP
flash visual evoked potential
- P-VEP
pattern reversal visual evoked potential
- RCT
retinocortical time |
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Keywords: | Dopamine agonist dopamine antagonist electroretinograms visual evoked potentials |
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