| 姜黄素联合人类细胞因子诱导的杀伤细胞对卵巢癌细胞增殖的抑制作用及其机制 |
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| 引用本文： | 单延红,张海军,徐志刚,崔满华.姜黄素联合人类细胞因子诱导的杀伤细胞对卵巢癌细胞增殖的抑制作用及其机制[J].吉林大学学报(医学版),2011,37(2):220-225. |
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| 作者姓名： | 单延红 张海军 徐志刚 崔满华 |
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| 作者单位： | 吉林大学第二医院妇产科,吉林,长春130041;吉林省长春市妇产医院妇产科,吉林,长春,130042;吉林省长春市妇产医院妇产科,吉林,长春,130042;江苏省苏州市泽璟生物制药有限公司;吉林大学第二医院妇产科,吉林,长春130041 |
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| 摘 要： | 目的:观察姜黄素(Cur)联合人类细胞因子诱导的杀伤(CIK)细胞在体外对人卵巢癌浆液性囊腺癌细胞SKOV-3的增殖抑制作用,探讨其协同抗肿瘤作用及其可能机制.方法:诱导脐血CIK细胞,将SKOV-3细胞随机分为Cur组、CIK细胞组和Cur联合CIK细胞组,MTT法测定各组细胞的增殖抑制率,RT-PCR检测各组细胞F...
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| 关 键 词： | 姜黄素 人类细胞因子诱导的杀伤细胞 卵巢癌细胞 细胞增殖 细胞凋亡 |
| 收稿时间： | 2010-12-17 |
Inhibitory effects of curcumin associated with CIK cells on proliferation of ovarian carcinoma cells and their mechanisms |
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| SHAN Yan-hong,ZHANG Hai-jun,XU Zhi-gang,CUI Man-hua.Inhibitory effects of curcumin associated with CIK cells on proliferation of ovarian carcinoma cells and their mechanisms[J].Journal of Jilin University: Med Ed,2011,37(2):220-225. |
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| Authors: | SHAN Yan-hong ZHANG Hai-jun XU Zhi-gang CUI Man-hua |
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| Affiliation: | 1. Department of Obstetrics and Gynecology,Second Hospital,Jilin University,Changchun 130041,China;2. Department of Obstetrics and Gynecology,Obstetric and Gynecologic Hospital of Changchun City, Changchun 130042,China)
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| Abstract: | Objective To observe the inhibitory effects of curcumin(Cur) associated with cytokine-induced killer(CIK) cells on proliferation of ovarian carcinoma SKOV-3 cells in vitro,and discuss whether they have synergetic anti-tumor effects if they are used together and the possible mechanism.Methods The CIK cells were induced from umbilicus cord blood,and the SKOV-3 cells were randomly divided into Cur group,CIK cells group and Cur associated with CIK cells group.The inhibitory rates of proliferation in each group ... |
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| Keywords: | curcumin cytokine-induced killer cells ovarian carcinoma cells cell proliferation apoptosis |
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