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| 复方奥硝唑栓剂的研制及质量控制 | |
| 引用本文： | 黎行山,陈吉生,陈永.复方奥硝唑栓剂的研制及质量控制[J].中国药房,2004,15(12):729-731. |
| 作者姓名： | 黎行山 陈吉生 陈永 |
| 作者单位： | 1. 广州港港湾医院,广州市,510700 2. 广州铁路中心医院,广州市,510080 3. 广东药学院实习生,广州市,510224 |
| 基金项目： | 广东省医药卫生科研项目 |
| 摘 要： | 目的 :建立复方奥硝唑栓剂的制备方法及质量控制标准。方法 :筛选基质 ,确定栓剂中主药成分及基质的组成与比例 ,并采用高效液相色谱法的内标法同时测定栓剂中奥硝唑及左氧氟沙星的含量。结果 :以奥硝唑及左氧氟沙星为主药 ,使用水溶性基质制备栓剂 ;奥硝唑及左氧氟沙星的平均回收率分别为100 65 %、98 86 % ,其相对标准差分别为2 20 %、1 28 %。结论 :该制剂制备工艺简单、质量稳定 ,质量控制方法简便、准确、精密度好。 |
| 关 键 词： | 奥硝唑 左氧氟沙星 栓剂 高效液相色谱法 |
| 文章编号： | 1001-0408(2004)12-0729-03 |
| 修稿时间： | 2003年12月25 |
Preparation and Quality Control of Compound Ornidazole Suppository |
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| LI Hangshan.Preparation and Quality Control of Compound Ornidazole Suppository[J].China Pharmacy,2004,15(12):729-731. | |
| Authors: | LI Hangshan |
| Abstract: | OBJECTIVE:To develop the preparation technic of compound ornidazole suppository and establish the quality standard.METHODS:The proper base material was picked out and the proportion of main ingredients to base material in suppository was defined.The contents of ornidazole and levofloxacin were determined by HPLC with an internal stanˉdard.RESULTS:The suppository was prepared with ornidazole and levofloxacin as main ingredient,and water-soluble base as materials.The average recovery rates of ornidazole and levofloxacin were100.65%(RSD=2.20%)and98.86%(RSD=1.28%)respectively.CONCLUSION:The preparation is simple in preparation technic,stable in quality,and convenient,accuˉrate and precise in quality control. |
| Keywords: | ornidazle levofloxacin suppository HPLC |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
