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| 丙泊酚联合地塞米松对早期脓毒症大鼠炎症因子的影响 | |
| 引用本文： | 雷贤英,甘辞海,钟庆,王丽,孙双春,周淑敏,缑剑.丙泊酚联合地塞米松对早期脓毒症大鼠炎症因子的影响[J].海南医学,2011,0(19):12-14. |
| 作者姓名： | 雷贤英 甘辞海 钟庆 王丽 孙双春 周淑敏 缑剑 |
| 作者单位： | 1. 泸州医学院附属医院ICU,四川 泸州,646000 2. 简阳市人民医院,四川 简阳,641400 3. 泸州医学院中心实验室,四川 泸州,646000 |
| 基金项目： | 四川省教育厅自然科学重点项目[编号:(川教函(2008)760号:09027)]; 泸州医学院青年基金项目[编号:(泸医院科(2009)1号:09008)] |
| 摘 要： | 目的观察丙泊酚联合地塞米松对早期脓毒症大鼠炎症因子的影响。方法采用大鼠尾静脉注射脂多糖复制脓毒症模型。按完全随机化原则分为5组：正常对照组（N）、脂多糖组（L）、脂多糖＋地塞米松组（LD）、LPS＋异丙酚组（LP组）、LPS＋异丙酚＋地塞米松组（LPD组）。各组大鼠于造模后麻醉处死,取腹主动脉血,用酶联免疫吸附法（ELISA）检测血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-6（IL-6）和白细胞介素-10（IL-10）。结果 L组TNF-α、IL-1β和IL-6较对照组明显升高,IL-10则明显降低（P均〈0.05）;LD组、LP组、LDP组同L组比较,其结果显示TNF-α、IL-1β和IL-6均明显降低,IL-10明显升高（P〈0.05;P〈0.05;P〈0.05）;LDP组同LP组、LD组比较,LDP组TNF-α、IL-1β和IL-6表达量明显下降,IL-10明显升高（P〈0.05）。结论 LPS可迅速引起TNF-α、IL-1β和IL-6的释放,抑制IL-10的表达;地塞米松、丙泊酚干预后,TNF-α、IL-1β和IL-6的量明显减少,IL-10明显升高,且两药联用干预效果更明显,对早期脓毒症大鼠有明显保护作用。 |
| 关 键 词： | 脓毒症 炎症因子 脂多糖 丙泊酚 地塞米松 |
Effect of propofol combined with dexamethasone on the inflammatory factors of early sepsis in rats |
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| LEI Xian-ying,GAN Ci-hai,ZHONG Qing,WANG Li,SUN Shuang-chun,ZHOU Shu-min,GOU Jian.Effect of propofol combined with dexamethasone on the inflammatory factors of early sepsis in rats[J].Hainan Medical Journal,2011,0(19):12-14. | |
| Authors: | LEI Xian-ying GAN Ci-hai ZHONG Qing WANG Li SUN Shuang-chun ZHOU Shu-min GOU Jian |
| Affiliation: | 1.1.Intensive Care Unit,the Affiliated Hospital of Luzhou Medical College,Luzhou 646000,Sichuan,CHINA;2.People＇s Hospital of Ji？ anyang City,Jianyang 641400,Sichuan,CHINA;3.Central Laboratory,Luzhou Medical College,Luzhou 646000,Sich？ uan,CHINA |
| Abstract: | Objective To observe the effect of propofol combined with dexamethasone on the inflammatory factors of early sepsis in rats.Methods Rats were randomly assigned into group N,group L,group LD,group LP,and group LPD,which underwent intravenous injection through the tail vein with 10 ml 0.9% Saline,lipopolysaccharide(LPS),LPS and dexamethasone,LPS and propofol,LPS and propofol plus dexamethasone,respectively.All the rats were killed through anesthesia,and their abdominal aortic blood were detected for the level... |
| Keywords: | Sepsis Inflammatory factors Lipopolysaccharide Propofol Dexamethasone |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |
