不同性别血浆脂蛋白(a)浓度与冠状动脉病变严重程度的关系

目的:研究中国不同性别血浆脂蛋白(a)Lp(a)]浓度与冠状动脉粥样硬化程度的关系。方法:将男女患者分别按冠状动脉狭窄程度分组,并计算冠状动脉病变积分,比较各组Lp(a)的差异及与冠状动脉积分的相关性。结果:无论男性还是女性,4组不同病变的Lp(a)浓度分布差异有统计学意义,P<0.01;仅多支病变组与0支病变组比较差异有统计学意义,女性P<0.01,男性P<0.05。绝经后女性Lp(a)水平高于绝经前,P<0.05。结论:在中国,Lp(a)水平与冠状动脉粥样硬化的严重程度成正相关关系,且女性和男性都存在。女性绝经后血浆Lp(a)浓度升高,血浆Lp(a)浓度受性激素的调节。

Association between plasma Lp(a) level and severity of coronary artery disease in different gender

Objective:To study possible association between plasma lipoprotein(a) (Lpa]) level and severity of coronary artery disease in different gender.Method:Four groups were classified according to gender and the numbers and extents of coronary artery with stenosis. Coronary stenosis score were evaluated respectively. The difference of Lp(a) among the four groups in male and female were analyze. The possible correlation between plasma Lp(a) level and coronary stenosis score was studied. Result:There was significant difference of Lp(a) among the four groups in both female and male (P<0.01). The difference only existed between multiple-vessel group and 0-vessel group. Plasma Lp(a) concentration was elevated in postmenopause female, compared with that in premenopause female. Conclusion:A positive correlation between plasma Lp(a) level and severity of coronary atherosclerosis exists in both male and female. Plasma Lp(a) concentration is hormonally regulated.