| ~1H-MRS分析鉴别胶质瘤术后复发与放射性脑损伤诊断价值 |
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| 引用本文： | 王静秋,付旷,彭晓刚,张蕊,卢敬红,倪海洋,赵雪峰.~1H-MRS分析鉴别胶质瘤术后复发与放射性脑损伤诊断价值[J].齐齐哈尔医学院学报,2012,33(16):2145-2147. |
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| 作者姓名： | 王静秋 付旷 彭晓刚 张蕊 卢敬红 倪海洋 赵雪峰 |
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| 作者单位： | 1. 黑龙江省哈尔滨医科大学第二临床医学院 150000
2. 黑龙江省齐齐哈尔市第一医院 |
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| 摘 要： | 目的 1 H-MRS鉴别脑胶质瘤术后复发与放射性脑损伤的价值。方法对18例脑胶质瘤术后放疗后出现异常强化区的患者进行1 H-MRS检查。分析复发和放射性脑损伤的1 H-MRS表现,对复发、损伤、正常脑白质病灶的Cho、Cr、NAA峰高与Cho/Cr、Cho/NAA值进行统计学分析,并根据ROC曲线确定比值参数(Cho/Cr、Cho/NAA)的最佳诊断阈值及诊断准确率。结果复发灶Cho/Cr(2.672士0.694)、Cho/NAA(3.116±1.016)高于损伤灶Cho/Cr(1.297±0.312)、Cho/NAA(1.335±0.253),差异有统计学意义(P<0.05)。结论 1 H-MRS可明显提高复发与损伤的鉴别诊断准确率,对放射性脑损伤的早期确诊具有重要应用价值。
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| 关 键 词： | 胶质瘤 复发 辐射损伤 |
Diagnostic Value of 1H-MRS analysis of multi - parameter in distinction of brain gliomarecurrence and post radiation brain injuries |
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| Affiliation: | WANG Jing-qiu,et al.(The Second Affiliated Hospital,Harbin Medical University,Heilongjiang 150000,the P.R.China.) |
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| Abstract: | Objective To investigate the value of 1H-MRSin distinction of brain glioma recurrence and post-radiation brain injuries. Methods Eighteen postoperative patients with abnormal enhancing lesions underwent 1H-MRS.Performances of glioma recurrence and post-radiation brain injuries on 1H-MRS were analyzed,ADC value of contralateral normal white matter and lesions,peaks height of Cho,Cr,NAA and Cho/Cr,Cho/NAA were measured and analyzed statistically. Results Cho/Cr(2.672士0.694).Cho/NAA(3.116±1.016)of recurrent lesions were significantly higher than those of injury lesions(1.297±0.312),(1.335±0.253),respectively(all P<0.05). Conclusions 1H-MRS multi-parameter analysis can improve the accuracy of differential diagnosis between brain glioma recurrence and post-radiation brain injuries,therefore have important application value on the early diagnosis of post-radiation brain injuries. |
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| Keywords: | Diffusion magnetic resonance imaging Glioma Recurrence Radiation injuries |
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