农村环境烟雾暴露与家族史对女性慢性支气管炎的交互作用研究

目的 探讨湖南省浏阳市农村女性环境烟雾暴露及慢性支气管炎(慢支)家族史与慢支的关系,及二者之间的交互作用.方法 采用以人群为基础的病例对照研究方法,应用X2检验分析环境烟雾暴露及慢支家族史与慢支的关系,应用相加效应模型分析农村女性环境烟雾暴露与慢支家族史的交互作用.结果 在第一阶段对农村24 268名女性居民筛查中发现慢支患者157例(患病率6.47‰),第二阶段病例对照研究最终调查慢支患者92例,健康对照114人.结果 显示,使用煤炭/柴草取暖(OR=36.21)及慢支家族史(OR=6.41)可能是女性患慢支的危险因素(P＜0.05);经常下厨及使用煤炭/柴草取暖与慢支家族史有明显的正交互作用,交互作用指数分别为5.39和9.02;交互作用归因危险比分别为72%和88%;交互作用相对超额危险度分别为6.50和225.99.结论 使用煤炭/柴草取暖和慢支家族史可能是女性慢支的危险因素,经常下厨、使用煤炭/柴草取暖与慢支家族史之间有正交互作用.

Interaction between exposure to environmental smoke and the family history of chronic bronchitis(CB)on the risk of CB in rural females in Liuyang city,Hunan province

Objective To explore the relationships and interaction among the exposure to environmental smoke,family history of chronic bronchitis(CB)and CB,in rural women.Methods A population-based case-control study χ~2 was used to analyze the relationship between environmental smoke exposure,CB family history and CB.Additive effects model was used to analyze the interaction.Results In the first stage,157 CB patients were screened from 24 268 women residents (prevalence rate is 6.47‰),then 92 patients(case group)and 114 healthy women(control group)were investigated in the second stage.Results showed that:coal/firewood for heating(OR=36.21)and CB family history(OR=6.41)might serve as the risk factors of CB in rural women(P＜0.05).Factors as frequent cooking and using coal/firewood for heating had a positive interaction with family history of CB in rural women,CB with S as 5.39 and 9.02,attributable proportions of interaction (API)as 72% and 88%,relative excess risk of interaction(RERI)as 6.50 and 225.99,respectively.Conclusion Using coal/firewood for heating and CB family history might be the risk factors of CB for rural women.A positive interaction between cooking frequently,heating model and CB family history was also seen.