| 肝康颗粒对ConA性肝损伤小鼠的保护作用及TNF-α影响的实验研究 |
| |
| 引用本文： | 卞锦喜,彭勃.肝康颗粒对ConA性肝损伤小鼠的保护作用及TNF-α影响的实验研究[J].世界中西医结合杂志,2006,1(3):142-144. |
| |
| 作者姓名： | 卞锦喜 彭勃 |
| |
| 作者单位： | 1. 河北医科大学,河北,石家庄,050091
2. 河南中医学院,河南,郑州,450003 |
| |
| 基金项目： | 河南省教育厅科研基金课题NO:2000360013 |
| |
| 摘 要： | 目的:观察肝康(GK)颗粒对刀豆蛋白A(ConA)性肝损伤小鼠的保护作用和对肿瘤坏死因子-α(TNF-α)的影响。方法:将50只小鼠随机分空白组、模型组和GK低、中、高剂量组,采用ConA诱导小鼠急性肝损伤,观察肝康颗粒对小鼠血清丙氨酸转氨酶(ALT)、总胆红素(TBil)及TNF-α水平的影响。结果:模型组ALT、TBil水平高于空白组(P<0．05或P<0．01),GK各剂量组ALT值均低于模型组(P<0．05或P<0．01);GK高剂量组TBil值低于模型组(P<0．05);GK中、高剂量组TNF-α低于模型组(P<0．01)。结论:肝康颗粒能降低ConA小鼠肝损伤血清ALT、TBil的水平,抑制TNF-α,对肝损伤有保护作用。
|
| 关 键 词： | 急性肝损伤 肝康颗粒 刀豆蛋白A 肿瘤坏死因子 丙氨酸转氨酶 总胆红素 小鼠 |
| 文章编号： | 1673-6613(2006)03-0142-03 |
| 修稿时间： | 2006年8月1日 |
Effect of Gankang Granules on TNF-α and Protection on Con A Liver Lesion in Mice |
| |
| Bian Jinxi,Peng Bo.Effect of Gankang Granules on TNF-α and Protection on Con A Liver Lesion in Mice[J].World Journal Of Integrated Traditional and Wesrern Medicine,2006,1(3):142-144. |
| |
| Authors: | Bian Jinxi Peng Bo |
| |
| Abstract: | Objective: To investigate the effect of Gankang Granules (GKG) on TNF-a and protection on ConA liver lesion in mice. Methods: The 50 mice were divided into blank, model and high, middle and low dosage of GK group, the model of acute liver lesion in mice was induced with ConA. The effects of GKG on ALT,TBil and TNF-a were measured. Results:The value of ALT and TBil in model group was higher than that in blank group(P<0. 05 or P<0. 01); all the values of ALT in each dosage GKG group were lower than that in model group(P<0. 05 or P<0. 01); the value of TBil in the high dosage group was lower than that in model group(P<0. 05); the values of TNF-a in the high and middle dosage groups were lower than that in model group(P<0. 01). Conclusion:GKG can lower the serum level of ALT and TBil of Con A liver lesion in mice, inhibit the value of TNF-a and protect the liver from the lesion. |
| |
| Keywords: | |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
