土槿皮的化学成分研究(英文)

对松科Pinaceae植物金钱松Pseudolarix kaempferi Gord的干燥根皮—土槿皮的化学成分进行了研究。应用硅胶,Sephadex LH-20,MCI柱色谱以及高效液相色谱等技术进行分离纯化,利用化合物的理化常数和波谱数据鉴定其结构。分离并鉴定了26个化合物,分别为:土槿丁酸(1),土槿甲酸(2),土槿乙酸(3),土槿丙酸(4),3β-乙酰氧基-齐墩果烷-11,13(18)二烯(5),3β-乙酰氧基-齐墩果烷-9(11),12二烯(6),3β-羟基-齐墩果烷-11,13(18)二烯(7),3β-羟基-齐墩果烷-9(11),12二烯(8),Celangulatin C(9),Celangulatin E(10),17β-通关藤苷元B(11),11α-O-(2-甲基丁酰基)-12β-O-乙酰基通关藤苷元B(12),11α-O-(2-甲基丁酰基)-12β-O-巴豆酰基(顺芷酰基)通关藤苷元B(13),β-谷甾醇酯(14),伞形花内酯(15),5,7-二羟基香豆素(16),花椒毒素(17),异虎耳草素(18),芒柄花黄素(19),毛蕊异黄酮(20),Cnidimol B(21),胸腺嘧啶(22),3-呋喃甲酸(23),2-呋喃甲酸(24),香草酸(25),原儿茶酸(26)。其中化合物5–24为首次从该植物中分离得到;并首次归属化合物1的1H和13CNMR谱数据。

Chemical constituents of Pseudolarix kaempferi Gord

Phytochemical investigations of Pseudolarix kaempferi Gord led to the isolation of 26 known compounds. They were identified as follows: pseudolaric acid D (1), pseudolaric acid A (2), pseudolaric acid B (3), pseudolaric acid C (4), oleana- 11,13(18) - dien-3β-O-acetyl (5), oleana- 9(11),12 -dien-3β-O-acetyl (6), oleana- 11,13(18)-dien-3β-hydroxyl (7), oleana- 9(11),12 -dien-3β-hydroxyl (8), celangulatin C (9), celangulatin E (10), 17β-tenacigenin B (11), 11α-O-2-methyl butyryl-12β-O-acetyl tenacigenin B (12), 11α-O-2-methyl butyryl-12β-O-tigloyl tenacigenin B (13), β-sitosterol acetate (14), umbelliferone (15), 5,7-dihydroxyl coumarin (16), xanthotoxin (17), isopimpinellin (18), formononetin (19), calycosin (20), cnidimol B (21), thymine (22), 3-furoic acid (23), 2-furoic acid (24), vanillic acid (25), protocatechuic acid (26). Compounds 5–24 were isolated from P. kaempferi for the first time. And the 1 H and 13 C NMR spectra of compound 1 were completely assigned for the first time.