甲状腺功能减退与子宫内膜癌的相关性分析

目的探讨甲状腺功能减退与子宫内膜癌(EC)的关系及EC患者癌组织分化程度和雌激素受体(ER)、孕激素受体(PR)的表达与甲状腺功能之间的关系。方法选取2015年1月—2018年7月我院收治的EC患者113例,同时随机选取年龄与EC组相匹配的此段时间内我院健康体检的妇女156例作为对照组,检测血清促甲状腺激素(TSH)、甲状腺激素(FT4)。比较两组间甲状腺功能减退的患病率,并利用免疫组织化学法测定EC患者手术切除标本的癌组织中ER、PR的表达,分析EC患者癌组织分化程度及癌组织中ER、PR的表达与甲状腺功能之间的相关性。结果 EC组甲状腺功能减退的患病率较对照组高(P<0.000)。低分化EC患者的TSH高于中分化EC患者(P=0.025)。EC手术切除标本的癌组织中ER、PR阳性与阴性患者的TSH、FT4差异无统计学意义(P>0.05)。结论甲状腺功能减退与EC具有相关性。

Correlation of Hypothyroidism and Endometrial Carcinoma

Objective To investigate the relationship between hypothyroidism and endometrial carcinoma, and to explore the relationship of the differentiation degree of endometrial carcinoma, the expression of estrogen receptor (ER) and progesterone receptor (PR) in cancer tissues with thyroid function of patients with endometrial carcinoma. Methods We collected 113 patients with endometrial carcinoma treated in our hospital from January 2015 to July 2018. A total of 156 women whose age matched with endometrial cancer group underwent physical examination in the physical examination center of our hospital during this period were randomly selected as control group. Serum thyroid stimulating hormone (TSH) and thyroid hormone (FT4) were measured. The prevalence of hypothyroidism was compared between the two groups. The expression of ER and PR in the excision specimen of cancer tissues were detected by immunohistochemistry. We analyzed the relationship of the differentiation degree of endometrial carcinoma, the expression of ER and PR in cancer tissues with thyroid function of patients with endometrial carcinoma. Results The prevalence of hypothyroidism was higher in the endometrial carcinoma group than that in the control group (P<0.000). The TSH of patients with poorly-differentiated endometrial cancer was higher than that of patients with moderately-differentiated endometrial cancer (P=0.025). There was no significant difference in TSH and FT4 between ER, PR positive and negative in the cancer tissues of patients with endometrial carcinoma (P>0.05). Conclusion Hypothyroidism is associated with endometrial cancer.