中西医结合治疗胰岛素抵抗型PCOS不孕的效果

目的探讨中西医结合治疗胰岛素抵抗型多囊卵巢综合征（PCOS）不孕的临床效果。方法将60例胰岛素抵抗型PCOS不孕病人随机分为A、B两组,各30例。A组以中药调经颗粒配合西药氯米芬（CC）、二甲双胍治疗;B组单纯应用CC、二甲双胍治疗。两组各治疗3个月,观察临床疗效及治疗前后血清空腹胰岛素（INS）、卵泡刺激素（FSH）、黄体生成素（LH）、LH/FSH、睾酮（T）水平。结果 A组疗效明显优于B组（uc=1.99,P〈0.05）。A、B两组治疗后血清INS、LH、T水平及LH/FSH较治疗前显著降低（t=2.23-13.86,P〈0.05、0.01）。A组治疗后血清INS、LH、T水平及LH/FSH下降较B组明显（t=2.59-3.86,P〈0.05）。A组副作用发生率低于B组（χ2=13.61,P〈0.01）。结论中西医结合治疗胰岛素抵抗型PCOS不孕的临床效果优于单用西药疗法,中医中药在该病治疗过程中发挥了独特的优势。

COMBINED TREATMENT OF TRADITIONAL CHINESE MEDICINE AND WESTERN MEDICINE FOR INSULIN-RESISTANT POLYCYSTIC OVARY SYNDROME-ASSOCIATED INFERTILITY

Objective To explore the clinical efficacy of combined Chinese and western medicine for insulin-resistant polycystic ovary syndrome-associated infertility（IRPCOSAI）. Methods Sixty IRPCOSAI patients were evenly randomized to groups A and B.Patients in group A were treated with combined Tiaojing particles（Chinese traditional medicine）,clomiphene citrate（CC） and metformin;Patients in group B simply received CC and metformin.After three months of treatment,clinical efficacy and changes in serum INS,FSH,LH,LH/FSH,and Testosterone（T） levels were analyzed. Results The clinical effect was significantly greater in group A than in group B（uc=1.99,P〈0.05）.There were significant decreases in serum INS,LH,LH/FSH and T in both groups after treatment（t=2.23-13.86;P〈0.05,0.01）.However,the decrease was significantly greater in group A than that in group B（t=2.59-3.86,P〈0.05）,and the adverse effect rate was lower（χ2=13.61,P〈0.01）. ConclusionThe combined therapy of Chinese and western medicine for insulin-resistant polycystic ovary syndrome-associated infertility was better than using western medicine alone,in which,Chinese medicine plays a distinct role.