H型高血压患者血清ADMA和血脂水平变化及其意义

目的:探讨H型高血压患者血清非对称性二甲基精氨酸(ADMA)、血脂水平的变化及其临床意义.方法:以2014年3月~2015年8月在我院接受治疗的110例高血压患者为观察对象,并根据其血清同型半胱氨酸(Hcy)水平分为H型高血压组(45例)和非H型高血压组(65例),同时选取50例健康成年人作为对照组.观察三组血清ADMA、血糖和血脂水平的差异,分析血清ADMA与血糖和血脂水平的相关性.结果:三组患者ADMA和MBG水平由高到低分别为:H型高血压组、非H型高血压组和对照组,差异具有统计学意义;三组患者的TC、LDL-C和TG水平由高到低分别为H型高血压组、非H型高血压组和对照组,HDL-C水平由高到低分别为对照组、非H型高血压组和H型高血压组,差异具有统计学意义;血清ADMA水平与MBG、TC、LDL-C和TG水平正相关,与HDL-C水平负相关.结论:H型高血压患者血清ADMA水平较高,且与患者的血脂和血糖水平显著相关.

Changes and significance of serum ADMA and serum lipid levels in patients with type H hypertension

Objective To investigate the changes of serum levels of H and serum levels of non symmetry two (ADMA) in patients with hypertension and its clinical significance. Methods 110 cases of hypertension patients treated in our hospital from March 2014 to August 2015 were selected as the observation object and according to the level of the serum homocysteine (Hcy) divided H-type hypertension group (45 cases) and non - H type hypertension group (65 cases), and select the 50 cases of healthy adults as the control group. Three groups of serum ADMA, blood glucose and blood lipid levels were observed, and the correlation between serum ADMA and blood glucose and blood lipid levels were analyzed. Results The levels of ADMA and MBG in the three groups were higher than that in the H group and the control group, the difference was statistically significant;The levels of TC, LDL-C and TG in three groups of patients from high to low are H H type hypertension group and non hy-pertension group and control group, HDL-C level from high to low, respectively, control group and non - H type hypertension group and H type hypertension group, the difference has statistical significance; Serum ADMA levels were positively correlated with MBG, TC, LDL-C and TG levels, and negatively correlated with HDL-C levels. Conclusion The level of serum ADMA in patients with type H hypertension is higher, and the blood lipid and blood glucose levels are significantly correlated.