两种胰岛素方案治疗门诊初诊2型糖尿病患者的疗效及低血糖发生率比较

目的研究两种胰岛素方案治疗门诊初诊2型糖尿病患者的疗效及低血糖发生率。方法选取孝感市中心医院2013年3月—2014年8月84例门诊初诊2型糖尿病患者,抽签随机分为两组,其中42例采用餐前皮下注射门冬胰岛素治疗记为对照组,剩下42例采用餐前注射门冬胰岛素联合晚间注射甘精胰岛素强化治疗记为观察组。结果两组治疗后血糖相关指标比较无明显差异,不具有统计学意义(P0.05);观察组低血糖率11.90%较对照组30.95%显著较低,具有统计学意义(P0.05)。结论两种胰岛素方案治疗初诊2型糖尿病均较为有效,但早期采用强化治疗方案能有效稳定平衡血糖代谢、预防低血糖发生,可作为临床治疗初诊2型糖尿病的首选参考方法。

Comparison of the Curative Effects of the Two Kinds of Insuiln Regimens in the Treatment of Outpatients With Newly Diagnosed Type 2 Diabetes and the Incidence of Hypoglycemia

Objective To study the curative effects of the two kinds of insulin regimens in the treatment of outpatients with newly diagnosed type 2diabetes and the incidence of hypoglycemia .Methods 84 cases of outpatients with newly diagnosed type 2 diabetes treated in our hospital from March 2013 to August 2014 were studied and were randomly divided into two groups by drawing lots of which 42 cases treated by subcutaneous injection of insulin aspart before meal were treated as the control group and the remaining 42 cases by injection of insulin aspart before meals combined with injection of insulin glargine intensive therapy at night were treated as the observation group.Results After treatment , the differences in blood glucose related indexes between the two groups were not statistically significant ( P>0.05 ); The rate of hypoglycemia in the observation group ( 11.90%) was significantly lower than that in the control group (30.95%) ( P<0.05 ) .Conclusion The two kinds of insulin regimens in treatment of newly diagnosed type 2 diabetes are effective but the application enhanced therapy can effectively stabilize and balance glucose metabolism and prevent the incidence of hypoglycemia which can be used as the first choice for clinical treatment of newly diagnosed type 2 diabetic patients.