血清25羟维生素D3水平与2型糖尿病大血管病变的关系研究

目的:探讨血清25-羟维生素D325(OH)D3]水平与2型糖尿病(type 2 diabetes mellitus,T2DM)大血管病变的关系?方法:选取T2DM患者189例,按照有无大血管病变分为单纯T2DM组104例?T2DM合并大血管病变组85例,100例无糖尿病者为正常对照组?对每位患者进行临床资料收集,常规生化指标?血清25(OH)D3水平检测;根据25(OH)D3水平由高到低按三分位法将患者分为25(OH)D3高?中?低3组,比较3组患者动脉硬化的发生情况? 结果:单纯T2DM组和T2DM合并大血管病变组的血清25(OH)D3水平显著低于正常对照组(P < 0.05);T2DM合并大血管病变组患者血清25(OH)D3水平显著降低,与单纯T2DM组比较差异有统计学意义(P < 0.05);按25(OH)D3水平由高到低进行分组的3组患者的大动脉粥样硬化的患病率也逐渐升高,分别为:14.29%?25.40%和48.73%,25 (OH)D3低水平组患者的大动脉粥样硬化的患病率显著高于25(OH)D3中?高水平组患者,差异有统计学意义(P均 < 0.05)?结论:血清25(OH)D3水平与T2DM大血管病变发生呈明显负相关,血清25(OH)D3水平降低可能增加糖尿病大血管病变的风险?

The correlation of serum 25-hydroxyvitamin D3 and macroangiopathy in type 2 diabetes mellitus

Objective:To evaluate the association of 25-hydroxyvitamin D325 (OH)D3] with macroangiopathy in type 2 diabetes mellitus (T2DM). Methods:There were 189 T2DM patients and 100 controls in study. The patients were divided into two groups (T2DM group and T2DM complicated with macroangiopathy group) based on their clinical features. Clinical data,metabolic indices and serum 25(OH)D3 levels were detected compared among all groups. According to the level of 25 (OH)D3,all patients were divided into 3 groups,low 25 (OH)D3 group,middle 25 (OH)D3 group and high 25 (OH)D3 group. The relevance of 25 (OH)D3 and other parameters were analyzed by Pearson correlation analysis. Results:The serum 25 (OH)D3 level in T2DM group or T2DM complicated with macroangiopathy group was significantly lower than that in the control group(P < 0.05),and the serum 25 (OH)D3 level in T2DM complicated with macroangiopathy group was significantly lower than that in the T2DM group (P < 0.05). From high 25(OH)D3 level group to low 25 (OH)D3 level group,the prevalence of macroangiopathy were increased from 14.29%,25.40% to 48.73%,respectively. The macroangiopathy prevalence in T2DM of low 25 (OH)D3 level group was significantly higher than the other two groups with high 25 (OH)D3 level(P < 0.05). Conclusion:The serum 25(OH)D3 level was negatively related with macroangiopathy in T2DM. The decreased serum levels of 25(OH)D3 maybe increase risk of macroangiopathy.