大环内酯类药物与结核病

结核病是由结核杆菌(MTB)感染引起的慢性传染病.入侵结核杆菌数量、毒力与宿主防御反应的抗衡决定结核病的转归.其中,由T细胞介导的细胞免疫和迟发型变态反应占主导地位.近年来,通过动物实验,以及大环内酯类药物在支气管哮喘、弥漫性泛细支气管炎、慢性鼻窦炎等疾病中的运用,已有大量研究表明,该类药物除具有一般抗菌作用外,尚可通过调节多种免疫细胞、影响细胞因子及炎症介质活性等发挥免疫调节作用,使其有望在新的作用途径开辟抗结核治疗的道路.

Macrolides and tuberculosis

Tuberculosis is a chronic infectious disease caused by MTB. The prognosis and outcome of the pa-tients with tuberculosis are closely correlated with the balance between MTB with the host, including the number or the virulence of MTB, the defense reaction of the host, etc. Among these factors, cell-mediated immunity and the delayed type hypersensitivity mediated by T cell. Plenty of researches showed that macroides have im-munomodulatory effects in animal experiments and clinical studies including asthma, diffuse panbronchiolitis, chronic sinusitis and other diseases, by modulating immune cell function and the activity of cytokine and inflam-matory mediators, except the anti-bacterial effect. It is expected that macroids will provide a new approach a-gainst Tuberculosis.