| 可溶性fms-样酪氨酸激酶受体-1不同基因片段对视网膜新生血管的抑制作用 |
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| 引用本文： | 张敏,吴强,宋蓓雯,贾丽丽,陆斌,杜新华.可溶性fms-样酪氨酸激酶受体-1不同基因片段对视网膜新生血管的抑制作用[J].中华眼底病杂志,2010,26(1):219-222. |
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| 作者姓名： | 张敏 吴强 宋蓓雯 贾丽丽 陆斌 杜新华 |
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| 作者单位： | 上海交通大学附属第六人民医院眼科,200233; |
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| 摘 要： | Objective To investigate the inhibitory effects of fms-like typrosine kinase receptor sFh-1 on retinal neovascularization (RNV). Methods Recombinant lentivirus sFh-1 ( 2-3 ) and sFh-1 ( 2-4 )expressing the sFh-1 (2-3) and (2-4) immunoglobulin-like regions of sFh-1 were constructed. 96 seven-dayold C57/6J mice were randomly divided into 4 groups with 24 mice in each group. Group 1 : normal control;group 2: experimental control; group 3: sFlt-1(2-3); group 4: sFlt-1(2-4). The mice in group 2-4 were exposed to hyperoxia with (75±2)% O2 for 5 days and then returned to normoxia with 21% O2 ; the mice
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| 关 键 词： | 视网膜新生血管化/预防和控制 血管内皮生长因子受体1/治疗应用 基因转移技术 动物实验 |
Inhibitory effects of various regions of soluble fins-like typrosine kinase receptor-1 on retinal neovascularization |
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| Abstract: | |
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| Keywords: | Retinal neovascularization/prevention & controlVascular endothelial growth factor receptor-1/therapeutic useGene transfer techniquesAnimal experimentation |
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