| 补骨脂雌激素样作用实验研究 |
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| 引用本文： | 李璘,邱蓉丽,乐巍,鞠晓云,范乃兵,宋宏绣,李寰舟.补骨脂雌激素样作用实验研究[J].辽宁中医药大学学报,2012(4):57-58. |
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| 作者姓名： | 李璘 邱蓉丽 乐巍 鞠晓云 范乃兵 宋宏绣 李寰舟 |
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| 作者单位： | 南京中医药大学 |
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| 基金项目： | 江苏省中医药管理局项目(LB09013);南京中医药大学国家基金预研基金资助项目(XYY06) |
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| 摘 要： | 目的:通过实验方法确定补骨脂是否具有雌激素样作用。方法:采用子宫增重实验、ELISA实验法,通过对幼龄小鼠子宫重理和血清中相关激素水平的影响,观测补骨脂是否具有雌激素样作用。结果:在子宫增重实验中,补骨脂明显升高动物子宫系数;在血清雌激素与睾酮含量水平测定实验中,补骨脂明显能升高小鼠的血清雌激素水平(P<0.01),同时,雄激素水平也有升高的趋势,但与正常组相比无明显差异。结论:补骨脂具有雌激素样作用,同时也影响了体内雄激素的水平。补骨脂可能通过提高下丘脑-垂体-性腺轴的敏感性,从而影响血清中雌性激素和雄性素,发挥双向调节的作用。
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| 关 键 词： | 补骨脂 雌激素 雄激素 ELISA |
Study on Phytoestrogenic Effect in Psoralea Colrylifolia |
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| LI Lin,QIU Rong-li,YUE Wei,JU Xiao-yun,FAN Nei-bing,SONG Hong-xiu,LI Huan-zhou.Study on Phytoestrogenic Effect in Psoralea Colrylifolia[J].Journal of Liaoning University of Traditional Chinese Medicine,2012(4):57-58. |
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| Authors: | LI Lin QIU Rong-li YUE Wei JU Xiao-yun FAN Nei-bing SONG Hong-xiu LI Huan-zhou |
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| Affiliation: | (Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China) |
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| Abstract: | Objective:To explore the phytoestrogenic effects of psoralea colrylifolia L.,the Chinese medicine.Methods:50 prefemale ICR mice were randomly divided into five main groups and after administered(op)for 7 days,blood was collected and serum was separated.At the same time,the uterine weight of mice in each group was weighted.The levels of E2 and T in serum were analyzed by ELISA assay.Results:Psoralea colrylifolia L could increase the uterine weight in premice and also markedly enhance the level of E2 and T in serum.Conclusion:Psoralea colrylifolia L show the estrogenic effects and it is highly recommended that the application of psoralea colrylifolia L on treating the kidney-yang Deficiency was relative to its phytoestrogenic effects. |
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| Keywords: | psoralea colrylifolia L estrogen androgen ELISA assay |
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