硝苯地平和卡托普利对高血压患者血浆、唾液、尿液心钠素浓度的影响

目的探讨心钠素（ＡＮＰ）在高血压发病中的作用。方法５２例原发性高血压（ＥＨ）患者，随机分组，应用硝苯地平或卡托普利治疗２周前后，测定血浆、唾液、尿液ＡＮＰ含量的变化，并与健康组对照。结果治疗前患者血浆、唾液、尿液中ＡＮＰ均高于对照组（Ｐ＜０．０１）。治疗２周后，高血压组ＳＢＰ、ＤＢＰ和血、唾液、尿液中ＡＮＰ较治疗前明显降低（Ｐ＜０．０１），而治疗组间比较差异无显著性（Ｐ＞０．０５），且唾液和尿液中ＡＮＰ与血浆中浓度有同样变化趋势。结论硝苯地平和卡托普利可能是通过抑制ＡＮＰ的产生和释放的某个环节而发挥其降压效果的。

Effects of Nifedipine and Captopril on Atrial Natriuretic Peptide in Plasma and Saliva and Urine of Hypertensive Patients

Aim\ This study was designed to observe the effect of nifedipine or captopril on atrial natriuretic peptide(ANP) content in plasma and saliva and urine of fifty two patients with essential hypertension . \ Methods\ ANP content in plasma and saliva and urine of fifty two patients were measured.\ Results\ That before medications the ANP in plasma and saliva and urine were higher than that control healthy subjects(P<0.01).\ After two weeks treatment of captopril or nifedipine SBP,DBP and ANP in plasma and saliva and urine were all significantly decreased(P<0.01).\ No significant difference In BP and ANP were found between subjects two treated groupss(P>0.05).\ The results suggest thatThe antihypertensive effect of captopril and nifedipine may be associated with their inhibition on producing and releasing ANP.\ Conclusion\ This random study also was to determine the ANP.