Electrochemical behavior of uric acid at a penicillamine self-assembled gold electrode |
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Authors: | Ling Mei Niu Nian Bing Li Wei Jun Kang |
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Affiliation: | (1) School of Public Health, Hebei Medical University, 050017 Shijiazhuang, P.R. China;(2) School of Chemistry and Chemical Engineering, Southwest University, 400715 Chongqing, P.R. China |
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Abstract: | The fabrication and electrochemical characteristics of a penicillamine (PCA) self-assembled monolayer modified gold electrode
were investigated. The electrode can enhance the electrochemical response of uric acid (UA), and the electrochemical reaction
of UA on the PCA electrode has been studied by cyclic voltammetry and differential pulse voltammetry. Some electrochemical
parameters, such as diffusion coefficient, standard rate constant, electron transfer coefficient and proton transfer number
have been determined for the electrochemical behavior on the PCA self-assembled monolayer electrode. The electrode reaction
of UA is an irreversible process, which is controlled by the diffusion of UA with two electrons and two protons transfer at
the PCA/Au electrode. In phosphate buffer (pH 5.0), the peak current is proportional to the concentration of UA in the range
of 6.0 × 10−5–7.0 × 10−4 mol L−1 and 2.0 × 10−5–7.0 × 10−4 mol L−1 for the cyclic voltammetry and differential pulse voltammetry methods with the detection limits of 5.0 × 10−6 and 3.0 × 10−6 mol L−1, respectively. The method can be applied to determine UA concentration in real samples. |
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Keywords: | : Penicillamine self-assembled monolayer uric acid |
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