|
|||||
|
|
| 兔颈动脉急性血栓的MRI分子影像学评价 | |
| 引用本文： | 王志红,刘怀军,吴文新,徐英进,宋利宏,田泽君,王藏海.兔颈动脉急性血栓的MRI分子影像学评价[J].中国医学影像技术,2010,26(3):414-417. |
| 作者姓名： | 王志红 刘怀军 吴文新 徐英进 宋利宏 田泽君 王藏海 |
| 作者单位： | 1. 河北医科大学第二医院神经内科,河北,石家庄,050000 2. 河北医科大学第二医院医学影像科,河北,石家庄,050000 3. 河北医科大学第二医院病理科,河北,石家庄,050000 4. 河北医科大学第二医院心内科,河北,石家庄,050000 |
| 摘 要： | 目的 评价纤维蛋白靶向结合MRI对比剂(EP-2104R)对兔颈动脉急性血栓的显示能力,并与非对比增强和Gd-DTPA增强MR进行对比.方法 用颈动脉外部损伤和阻塞的方法制作5只兔颈动脉内血栓模型,在血栓诱导后急性期(6.0 h)进行对比剂EP-2104R注入前及注入后MR扫描,并与组织病理学对比.结果 纤维蛋白靶向对比剂能准确显示血栓,优于非对比增强MRI和Gd-DTPA增强MRI(P<0.001).Gd-DTPA增强后不能提高发现血栓的能力.结论 纤维蛋白靶向对比剂在显示活体内急性血栓方面优于非对比增强和Gd-DTPA增强MRI. |
| 关 键 词： | 兔 颈动脉 血栓形成 磁共振成像 分子影像学 |
| 收稿时间： | 2009/8/12 0:00:00 |
| 修稿时间： | 2009/11/19 0:00:00 |
Molecular MRI evaluation of acute thrombus in carotid artery in rabbits |
|
| WANG Zhi-hong,LIU Huai-jun,WU Wen-xin,XU Ying-jin,SONG Li-hong,TIAN Ze-jun and WANG Cang-hai.Molecular MRI evaluation of acute thrombus in carotid artery in rabbits[J].Chinese Journal of Medical Imaging Technology,2010,26(3):414-417. | |
| Authors: | WANG Zhi-hong LIU Huai-jun WU Wen-xin XU Ying-jin SONG Li-hong TIAN Ze-jun and WANG Cang-hai |
| Affiliation: | Department of Neurology, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Medical Imaging, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Pathology, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Medical Imaging, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Medical Imaging, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Cardiology, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China;Department of Medical Imaging, Second Hospital ofHebei Medical University, Shijiazhuang 050000, China |
| Abstract: | Objective To assess the value of a fibrin-targeted contrast agent(EP-2104R) for MR detection of thrombus,and to compare this modality with non-contrast-enhanced(NCE) MRI and Gd-DTPA injection at acute period after thrombus generation.Methods Thrombus was induced with external injury and stasis in 5 rabbits.MRI was performed before and after contrast agent injection at 6.0 h after injury,and the MRI findings were compared with that of histopathologically examinations.Results EP-2104R enhanced MRI accurately ... |
| Keywords: | Rabbits Carotid arteries Thrombosis Magnetic resonance imaging Molecular imaging |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |
| 点击此处可从《中国医学影像技术》浏览原始摘要信息 | |
| 点击此处可从《中国医学影像技术》下载全文 | |
