P33ING1在胃癌组织中的表达及其意义

目的：探讨P33ING1表达在 胃癌发生、发展过程中的病理生物学及临床意义。方法: 应用免疫组 化EnVision法,分别检测了原发性胃癌（71例）、胃粘膜不典型增生（12例）、正常胃粘膜 或慢性胃炎粘膜（18例）组织中P33ING1的表达，以及P53和Bcl-2在胃癌组织中的表 达情况。结果:胃粘膜不典型增生组及对照组（正常胃粘膜或慢性胃炎 粘膜）P33ING1均呈阳性表达，胃癌组织P33ING1表达率仅为62.0%(44/71),显 著低于前两组（P<0.01)。胃癌组织中P33ING1表达与肿瘤的浸润、淋巴结的转 移 及分化有关（P<0.01)；P53表达与肿瘤大小、浸润、淋巴结转移有关（P<0.01)；B cl-2与肿瘤的淋巴结转移及分化有关（P<0.05）。P33ING1与P53在胃癌组织中 的表达有相关性（P<0.05），与Bcl-2则无相关性。结论:P33 ING1在胃癌组织中表达下降，对胃癌发生、发展可能起重要作用。同时检测P33ING 1与P53的表达水平，对于原发性胃癌的诊断和治疗可能具有积极意义。

Expression of P33ING1 in stomach cancer and its clinical significance

Objective:To discuss the pathological relationship between P33 ING1 and stomach cancer and its clinical significance. Methods: In 71 cases of stomach cancer specimen, twelve cases of gastric mucous membrane atypical hyperplasia tissues and 18 cases of normal gastric mucous membrane tissue(as control),the expression of P33 ING1 were detected by EnVision immunohistochemical method,while the expression of P53 and Bcl 2 in stomach cancer were also detected. Results: P33 ING1 expression in mucous membrane atypical hyperplasia group and control group was positive, the expression in stomach cancer group was extremely low(62.0%,44/71), significantly different from the other 2 groups( P <0.01).P33 ING1 expression in stomach cancer was related to the tumor growth, lymph node metastasis and tumor polarization ( P <0.01), P53 expression was related to tumor size, growth and lymph node metastasis ( P <0.01). Bcl 2 expression was related to lymph node metatasis and tumor polarization.The expression of P33 ING1 was related to that of P53 in stomach cancer( P <0.05),while had no relation with that of Bcl 2.Conclusion:P33 ING1 may play an important role in the occurrance and development of stomach cancer.It's very important to detect the expression of P33 ING1 and P53 simultaneously.