4'-甲基立可定对冠脉血流和家兔实验性心肌梗塞的影响

实验表明4′-甲基立可定具有增加家免冠脉血流量和小白鼠心肌营养性血流量的作用,但对家兔心肌收缩力和心率无明显影响。通过对家兔实验性心肌梗塞疗效的观察,证明4′-甲基立可定可改善结扎冠脉后引起的心电图变化,表现为∑ST明显降低,NST和TO显著减少,NBT染色法也证明用药后梗塞心肌的重量明显减轻。与立可定进行对比研究指出,二者作用基本相似,唯后者增加心肌营养性血流的作用不够明显。

THE EFFECT OF 4'-METHYLRECORDIL ON CORONARY ARTERY BLOOD FLOW AND EXPERIMENTAL MYOCARDIAL INFARCTION IN RABBITS

According to Langendorff's method, 4'-methylrecordil and recordil were infused into the isolated rabbit heart. It was shown that these drugs increased coronary artery blood flow, but did no change the myocardial contractibility and heart rate. A study of the uptake of ⁸⁶Rb by the mouse heart showed a marked increase of nutritional blood flow in the 4'-methylrecordil-treated group and persantine-treated group, but no such effect was observed in the recordil-treated and control groups.In order to determine the effect of the drugs on experimental myocardial infarction, we have Produced the model of myocardial infarction by high level doublerligation of the anterior descending branch of the left coronary artery in rabbits. The size of infarcted myocardium and the therapeutic effect of drugs were estimated by using the summation of ST segment elevation (ΣST), the total numbers of ECG lead with elevated ST segment (NST) and pathologic Q wave (NQ), and myocardium N-BT staining method. After ligation of the coronary artery, all animals were given introvenously the drugs immediately, then once every 12 hours, for a total of six doses. The animals were sacrificed three days after operation. It was demonstrated that in the 4'-methylrecordil-treated group, the ΣST, NST and NQ were significantly less than those in the control group. The size of infarct myocardium was also reduced significantly. Similar results were found in the recordil and persantine-treated groups. However, no obvious difference was present among the treated groups.