| 粉防己碱对大鼠离体主动脉条45Ca内流的影响 |
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| 引用本文： | 唐仲进,王秀英,陈红,关英,朱铨英,苏定冯.粉防己碱对大鼠离体主动脉条45Ca内流的影响[J].药学实践杂志,1995,13(2):72-75. |
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| 作者姓名： | 唐仲进 王秀英 陈红 关英 朱铨英 苏定冯 |
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| 作者单位： | 第二军医大学基础部药理学教研室，福建省平和县芦溪乡卫生院 |
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| 摘 要： | 本文研究了粉防己碱（Ｔｅｔｒａｄｒｉｎｅ，Ｔｅｔ）对大鼠离体胸主动脉条~（４５）Ｃａ内流的影响。结果表明，粉防己碱（３×１０~（－５）ｍｏｌ·Ｌ~（－１））与维拉帕米（Ｖｅｒａｐａｍｉｌ，浓度为１×１０~（－５）ｍｏｌ·Ｌ~（－１））相似，可以抑制高Ｋ~＋激发的主动脉条~（４５）Ｃａ的内流量，但不能阻断由苯肾上腺素（Ｐｈｅｎｙｌｅｐｈｒｉｎｅ，浓度为１×１０~（－５）ｍｏｌ·Ｌ~（－１））激发的~（４５）Ｃａ内流量。结果提示，粉防己碱可能是选择性地阻断电压操纵的钙通道而抑制~（４５）Ｃａ内流。
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| 关 键 词： | 粉防己碱 苯肾上腺素 钙通道 钾 钙 主动脉条 |
Effect of tetrandrine on 45Ca influx in rat aorta in vitro |
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| Tang Zhong-jin,Wang Xiu-ying,Chen Hong,Guan Ying,Zhu Quan-ying and Su Ding-feng.Effect of tetrandrine on 45Ca influx in rat aorta in vitro[J].The Journal of Pharmaceutical Practice,1995,13(2):72-75. |
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| Authors: | Tang Zhong-jin Wang Xiu-ying Chen Hong Guan Ying Zhu Quan-ying and Su Ding-feng |
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| Affiliation: | Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433;Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433;Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433;Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433;Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433;Department of Pharmacology, Faculty of Basic Medincine, Second Military Medical University Shanghai 200433 |
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| Abstract: | The effects of tetrandrine on calcium influx were studied in rat aorta in vitro.It was found that tetrandrine, similar to verapamil, significantly inhibited high-K -induced 45Ca influx. But tetrandrine could not inhibit 45Ca influx evoked by phenylephrine, These results suggest that tetrandrine has a specific inhibitary effect on smooth muscle 45Ca influx by inhibiting voltage-operated calcium channel. |
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| Keywords: | tetrandrine high-K+ phenylephrine 45Ca calcium channel |
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