| 大蒜提取液对细胞生长,细胞周期进展及蛋白激酶C活性的影响 |
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| 引用本文： | 任中秀,余应年.大蒜提取液对细胞生长,细胞周期进展及蛋白激酶C活性的影响[J].中国病理生理杂志,1993,9(2):268-271. |
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| 作者姓名： | 任中秀 余应年 |
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| 作者单位： | 黑龙江大庆职工医学院，浙江医科大学病理生理教研室，浙江医科大学病理生理教研室 杭州 310006，杭州 310006 |
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| 摘 要： | 实验证明大蒜提取液对人羊膜FL细胞株的细胞增殖有抑制作用,其作用环节在细胞周期的G_2/M期;适当浓度的大蒜提取液对促癌剂12-0-十四酰基-佛波醇-13-乙酸酯(TPA)诱发的蛋白激酶-C(PK-C)活性变化有拮抗作用,但大蒜提取液在较高浓度时本身能引起类似于TPA诱发的PK-C活性变化。
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| 关 键 词： | 大蒜 蛋白激酶 有丝分裂周期 肿瘤 |
Effects of garlic extract on cell growth, cell cycle progression and protein kinase C activity in mammalian cells |
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| Ren Zhong-Xiu,Yu Ying-Nian,et al.Effects of garlic extract on cell growth, cell cycle progression and protein kinase C activity in mammalian cells[J].Chinese Journal of Pathophysiology,1993,9(2):268-271. |
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| Authors: | Ren Zhong-Xiu Yu Ying-Nian |
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| Affiliation: | Ren Zhong-Xiu,Yu Ying-Nian,et al Department of Pathophysiology,Zhejiang Medical University,Hangzhou |
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| Abstract: | The possible mechanism of tumor promotion inhibiting activity of garlicextract was studied. The garlic extract could inhibit the cell proliferation of human amnionFL cell in vitro, exerting no influence on the S phase DNA synthesis while exhibitingobvious inhibitory effect on the mitosis of the cells. At suitable concentration, garlic ex-tract could also inhibit the changes of protein kinase C activity induced by tumor promoterTPA, while at higher concentration garlic extract itself could induce changes of proteinkinase C activity mimic to TPA stimulation. |
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| Keywords: | Garlic Cell cycle Protein kinase |
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