VEGF与Notch1在乳腺癌浸润和转移中的作用及其相关性

目的探讨血管内皮生长因子(VEGF)和Notch1在乳腺癌组织中的表达及与肿瘤浸润和转移之间的关系。方法采用免疫组化S-P法检测VEGF和Notch1蛋白在60例乳腺癌组织及20例癌旁正常乳腺组织中的表达情况,并分析两者与乳腺癌患者临床病理学特征的关系。结果 VEGF和Notch1蛋白在乳腺癌组织中的表达高于癌旁正常组织(P均<0.05)。VEGF的表达与乳腺癌的淋巴结转移、组织学分级、临床分期有关(P均<0.05),Notch1蛋白的表达与乳腺癌的淋巴结转移、组织学分级有关(P均<0.05),两者在乳腺癌组织中的表达呈正相关关系(r=0.414,P=0.001)。结论 VEGF和Notch1可能在乳腺癌的发生、发展中起重要作用,两者的高表达有可能作为预测乳腺癌浸润、转移的指标。

Effect and correlation of VEGF and Notch1 in Invasion and Metastasis of Breast Cancer

Objective To investigate the expressions of vascular endothelial growth factor （VEGF） and Notch1 in the breast cancer tissues and the correlations with invasion and metastasis of breast cancer. Methods Immuno- histochemieal S-P method was used to detect the expressions of VEGF and Notch1 in 60 eases of breast cancer tis- sues and 20 cases of adjacent normal breast tissues, and the relationship between VEGF or Notch1 expressions and clinieopathologieal features of breast cancer was analyzed. Results The expressions of VEGF and Notch1 in breast cancer tissues were remarkably higher than those in the normal breast tissues （ P 〈 0.05 ）. The expressions of VEGF in breast cancer were related with the lymph node metastasis, histological grade and clinical stage （P 〈 0.05 ）. The expressions of Notehl in breast cancer were related with the lymph node metastasis and histological grade （ P 〈 0.05 ）. The expressions of VEGF were positively correlated to the expressions of Notehl （ r = 0. 414, P = 0. 001 ）. Conclusion VEGF and Notch1 may play the important role in the pathway of carcinogenesis and pro- gression of breast cancer, the up-regulation of VEGF and Notch1 expressions can predict the invasion and metastasis of breast cancer.