| 葛根素防治大鼠蛛网膜下腔出血后脑血管痉挛的实验研究 |
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| 引用本文： | 李铭,高觉民,吴颐,汤忠华,樊炼,傅传经,叶明,史德志.葛根素防治大鼠蛛网膜下腔出血后脑血管痉挛的实验研究[J].江西中医学院学报,2011,23(5):63-66. |
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| 作者姓名： | 李铭 高觉民 吴颐 汤忠华 樊炼 傅传经 叶明 史德志 |
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| 作者单位： | 南京中医药大学附属医院,江苏省中医院 南京,210029 |
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| 基金项目： | 江苏省中医药管理局课题 |
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| 摘 要： | 目的:研究葛根素对不同时期大鼠脑血管痉挛的防治作用。方法:采用枕大池二次注血法建立大鼠SAH模型,然后将56只健康雄性SD大鼠按各时间点(假手术组、SAH 3d组、SAH 5d组、SAH 7d组、葛根素3d组、葛根素5d组、葛根素7d组)分成7组,葛根素组在术后每天一次给予葛根素注射液治疗。于各时间点将各组大鼠灌注-固定,处死后取基底动脉切片常规行HE染色观察,通过图像分析系统测定动脉管径及血管壁厚度。结果:经葛根素治疗后,7d治疗组基底动脉内径周长明显大于蛛网膜下腔出血组(P<0.05)。病理组织学表明,痉挛血管的形态学得到改善。结论:葛根素对大鼠蛛网膜下腔出血后迟发性脑血管痉挛有一定的改善作用。
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| 关 键 词： | 蛛网膜下腔出血 脑血管痉挛 基底动脉 葛根素 |
Puerarin in Rats During Cerebral Vasospasm after Subarachnoid Hemorrhage Inexperimental Study |
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| LI Ming,GAO Jue-min,WU Yi,TANG Zhong-hua,FAN Lian,FU Chuan-jing,YE Ming,SHI De-zhi.Puerarin in Rats During Cerebral Vasospasm after Subarachnoid Hemorrhage Inexperimental Study[J].Journal of Jiangxi College of Traditional Chinese Medicine,2011,23(5):63-66. |
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| Authors: | LI Ming GAO Jue-min WU Yi TANG Zhong-hua FAN Lian FU Chuan-jing YE Ming SHI De-zhi |
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| Affiliation: | LI Ming,GAO Jue-min,WU Yi,TANG Zhong-hua,FAN Lian,FU Chuan-jing,YE Ming,SHI De-zhi Affiliated hospital of Nanjing University of Chinese Medicine,Jiangsu traditional Chinese medicine hospital,Nanjing 210029 |
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| Abstract: | Objective:To Study different period puerarin rats vasospasm preventive effect.Methods:Adopt pillow big pool second note blood method to establish the rat SAH model,and will only healthy male 56 SD rats by each time point(JiaShouShu group,SAH 3d group,SAH 5d group,SAH 7d group,puerarin grain 3d group,puerarin grain 5d group,puerarin grain 7d group) into seven group,once a day of puerarin in the puerarin consociation sibeline cure to treatment.Each time points in each rat perfusion-fixed,put to death take bas... |
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| Keywords: | Subarachnoid hemorrhage Cerebral vasospasm Basal artery Puerarin |
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