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| 上皮型钙黏蛋白在子宫内膜癌中的表达 | |
| 引用本文： | 狄文,方秀丽,丁传伟,朱建善,林其德.上皮型钙黏蛋白在子宫内膜癌中的表达[J].上海医学,2003,26(10):720-722,T001. |
| 作者姓名： | 狄文 方秀丽 丁传伟 朱建善 林其德 |
| 作者单位： | 1. 200001,上海第二医科大学附属仁济医院妇产科 2. 厦门市中山医院妇产科 3. 200001,上海第二医科大学附属仁济医院病理科 |
| 摘 要： | 目的 探讨上皮型钙粘蛋白 (E cadherin ,E cad)在子宫内膜癌中的表达意义。方法 采用免疫组织化学方法检测 16例子宫内膜癌及 10例子宫肌瘤、卵巢囊肿患者 (对照组 )的E cad表达。结果 子宫内膜癌患者的E cad表达阳性率较对照组显著增高 (P <0 .0 5 )。子宫内膜癌E cad表达水平 :①与临床分期相关 ,临床早期表达显著高于晚期 (P <0 .0 5 ) ;②与肿瘤细胞分化程度相关 ,分化越差 ,表达越低 (P <0 .0 5 ) ;③与子宫肌层浸润深度成反比 ,浸润肌层越深表达越低 (P <0 .0 5 )。结论 E cad在子宫内膜癌的侵袭转移中发挥重要的作用 ,它的丢失是癌细胞发生侵袭性生长过程中的关键环节 |
| 关 键 词： | 上皮型钙黏蛋白 子宫内膜癌 免疫组织化学 检测 肿瘤侵袭 肿瘤转移 |
E-cadherin expression the in carcinoma of endometrium |
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| DI Wen,FANG Xiuli,DING Chuanwei,et al..E-cadherin expression the in carcinoma of endometrium[J].Shanghai Medical Journal,2003,26(10):720-722,T001. | |
| Authors: | DI Wen FANG Xiuli DING Chuanwei |
| Affiliation: | DI Wen,FANG Xiuli,DING Chuanwei,et al. Department of Obstetrics and Gynecology,Renji Hospital,Shanghai Second Medical University,Shanghai 200001,China |
| Abstract: | Objective To investigate the expression of E-cadherin(E-cad) in the carcinoma of endometrium. Methods We examined the E-cad expression in 16 cases of carcinoma of endometrium and 10 cases of fibromyoma or ovarian cyst as control by immunohistochemistry. Results E-cad expression in carcinoma of endometrium group was higher than that of the control group(P<0.05); E-cad expression decreased with loss of differentiation and was inversely correlated with the depth of myometrial invasion(P<0.05) in carcinoma of endometrium. Conclusion The loss of E-cad plays an important role in the invasion and metastasis of carcinoma of endometrium. |
| Keywords: | E-cadherin Carcinoma of endometrium Immunohistochemistry |
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