| Cortactin蛋白在结直肠癌中的表达变化及其临床意义 |
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| 引用本文： | 张彤彤,梁建伟,王征,张钰,刘一臻,商利,杨海,蔡岩,徐昕,王明荣.Cortactin蛋白在结直肠癌中的表达变化及其临床意义[J].癌变．畸变．突变,2014,0(1):20-23. |
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| 作者姓名： | 张彤彤 梁建伟 王征 张钰 刘一臻 商利 杨海 蔡岩 徐昕 王明荣 |
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| 作者单位： | 中国医学科学院北京协和医学院肿瘤研究所分子肿瘤学国家重点实验室;中国医学科学院北京协和医学院肿瘤研究所普外科; |
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| 基金项目： | 卫生行业公益专项(200902002-5);863重大专项(2012AA022403,2012AA020206) |
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| 摘 要： | 目的：探讨Cortactin（CTTN）蛋白在结直肠癌组织中的表达变化及其临床意义。方法：采用免疫组织化学法检测100例结直肠癌组织和癌旁正常组织中CTTN蛋白的表达情况，分析CTTN蛋白的表达变化与结直肠癌患者临床病理指标及预后的关系。结果：CTTN蛋白在结直肠癌组织中的阳性表达率为58%，显著高于癌旁正常组织的6%（P＜0.01）。CTTN蛋白（P＜0.05）阳性表达率在不同的T分期（浸润深度）间的差异有统计学意义，而与患者的性别、年龄、肿瘤原发部位、肿瘤大小和淋巴结转移均无显著相关（P＞0.05）。生存分析的结果显示，CTTN阳性患者的预后差于CTTN阴性患者（P=0.014）。结论：CTTN蛋白在结直肠癌中表达增加，并与结直肠肿瘤的浸润深度有关，可能作为结直肠癌预后判断的指标。
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| 关 键 词： | Cortactin 结直肠癌 免疫组织化学 预后 |
Altered expression and prognostic significance of cor tactin in colorectal cancer |
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| ZHANG Tong-tong,LIANG Jian-wei,WANG Zheng,ZHANG Yu,LIU Yi-zhen,SHANG Li,YANG Hai,CAI Yan,XU Xin,WANG Ming-rong.Altered expression and prognostic significance of cor tactin in colorectal cancer[J].Carcinogenesis,Teratogenesis and Mutagenesis,2014,0(1):20-23. |
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| Authors: | ZHANG Tong-tong LIANG Jian-wei WANG Zheng ZHANG Yu LIU Yi-zhen SHANG Li YANG Hai CAI Yan XU Xin WANG Ming-rong |
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| Affiliation: | 1. State Key Laboratory of Molecular Oncology CancerInstitute ＆ Hospital,Peking Union Medical College and ChineseAcademy of Medical Sciences,Beijing 100021;2. Department ofAbdominal Surgical Oncology,Cancer Institute ＆ Hospital,PekingUnion Medical College and Chinese Academy of MedicalSciences,Beijing 100021, China) |
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| Abstract: | OBJECTIVE：To investigate the alteration of cortactin （CTTN） expression in colorectal cancer （CRC） and its correlation with clinico-pathological characteristics and prognosis. METHODS：Immunohistochemistry method was used to detect the expression of CTTN in 100 cases of CRC and adjacent normal tissues. The relationship between CTTN expression and clinico-pathological features and prognosis of the patients was evaluated. RESULTS：Positive rate of CTTN expression in colorectal cancer tissues was significantly higher than that in adjacent normal tissues （P〈0.01）. Expression of CTTN was correlated with depth of tumor invasion （P=0.037）. A Kaplan-Meier survival analysis revealed that the patients with CTTN expression had a shorter overall survival （OS） than those with negative CTTN （P=0.014）. CONCLUSION：CTTN overexpression was a common event,and seemed to be a poor prognostic factor for colorectal cancer. |
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| Keywords: | Cortactin colorectal cancer immunohistochemistry prognosis |
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