蒲地蓝消炎口服液与利巴韦林分散片治疗小儿手足口病的疗效比较

目的:观察比较蒲地蓝消炎口服液与利巴韦林分散片治疗小儿手足口病的疗效,探讨更优的治疗方案。方法:选取本院确诊为手足口病的患儿220例,随机分为治疗组和对照组,其中对照组110例,采用常规补液对症治疗基础上加用利巴韦林分散片治疗,治疗组110例,在常规治疗基础上加用蒲地蓝消炎口服液治疗,疗程均为5 d,治疗结束后比较两组患儿临床治疗总有效率、皮疹、疱疹消退时间、体温恢复正常时间,人轮状病毒抗原(RV-Ag)转阴率及不良反应情况等。结果:治疗组总有效率为93.3%,高于对照组76.2%(P0.05),治疗组3,5 d RV-Ag转阴率分别为85.8%和92.20%,高于对照组71.30%和75.51%(P0.05);治疗组的皮疹、疱疹消退时间为(2.77±0.54),(2.91±0.70)d,体温恢复正常时间为(3.37±0.61)d,均略低于对照组(P0.05);两组不良反应发生率差异无明显统计学意义。结论:蒲地蓝消炎口服液与利巴韦林分散片均可用于小儿手足口病,均可在一定程度上缓解手足口病患儿症状,蒲地蓝消炎口服液的症状消退速度更快,同时无明显不良反应,其机制与蒲地蓝消炎口服液的抗炎、抗病毒合成作用有关。蒲地蓝消毒口服液可有效治疗小儿手足口病,值得临床推广。

Effect of Pudilan Xiaoyan Oral Liquid and Ribavirin in Treatment of Children with Hand Foot Mouth Disease

Objective: The aim of this study was to observe and compare the curative effect of Pudilan Xiaoyan oral liquid and ribavirin in the treatment of children with hand foot and mouth disease,to obtain a better therapy. Method: In this study, two hundred and twenty cases diagnosed as hand foot and mouth disease in our hospital from 2010 May to 2013 December were selected and randomly divided into observation group and control group, with 110 patients in control group by conventional rehydration, symptomatic treatment based on the use of ribavirin treatment, and 110 cases in observation group, in the conventional treatment based on the use of Pudilan Xiaoyan oral liquid treatment. The treatment course lasted for 5 days, and the clinical treatment effects were compared between the two groups, including total efficiency, rash, bleb subsidise time, time for body temperature recovery, RV-Ag negative conversion rate and adverse circumstances etc. Result: The total effective rate of observation group was 93.3%, higher than 76.2% of the control group (P <0.05), the observation group 3 days and 5RV-Ag negative rate were 85.8% and 92.20% in the observation group, higher than 71.30%, 75.51%in the control group (P <0.05);the rash, bleb subsidise time in the observation group is (2.77±0.54) d and (2.91±0.70) d, time for body temperature recovery is (3.37±0.61) d, all were slightly lower than those of the control group (P <0.05);between the two groups, the difference in adverse reaction rate was not statistically significant. Conclusion: Pudilan Xiaoyan oral liquid and ribavirin can be used in the treatment in children with hand foot mouth disease, which can, to some extent, alleviate symptoms in children with hand foot and mouth disease, Pudilan Xiaoyan oral liquid has stronger ability to inhibit the proliferation of the virus, the symptoms subsided faster, and no obvious adverse reaction was observed. And the mechanism is related to the anti-inflammatory and antiviral synthesis effect of Pudilan Xiaoyan oral liquid. Pudilan Xiaoyan disinfection oral liquid is effective in the treatment in children with hand foot and mouth disease, and is worth of the clinical promotion.