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| 两亲性嵌段共聚物胶束的制备及对药物的控制释放 | |
| 引用本文： | 孟立山,陈金丽,姚新建.两亲性嵌段共聚物胶束的制备及对药物的控制释放[J].辽宁化工,2010,39(8):824-826. |
| 作者姓名： | 孟立山 陈金丽 姚新建 |
| 作者单位： | 1. 周口师范学院化学系,河南,周口466001;周口市安全生产培训中心,河南,周口466000 2. 河南省周口水文水资源勘测局,河南,周口,466000 3. 周口师范学院化学系,河南,周口466001 |
| 基金项目： | 河南省教育厅2010年度自然科学研究计划项目 |
| 摘 要： | 两亲性嵌段共聚物在水溶液中通过自组装可以形成以疏水嵌段为核，以亲水嵌段为壳的胶束。其亲水嵌段对胶束起稳定和保护作用，在胶束中通过物理、化学方式载入药物，可以实现对药物的控制释放。简述了嵌段共聚物胶束化的一些基本途径，如利用氢键，离子间相互作用，改变温度，自由基共聚，改变外部环境pH等，探讨了其对模型药物的控制释放。 |
| 关 键 词： | 两亲性 嵌段共聚物 药物控制释放 |
Synthesis of Amphiphilic Block Copolymer and Controlled Release in Drug Delivery System |
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| MENG Li-shan,CHEN Jin-li,YAO Xin-jian.Synthesis of Amphiphilic Block Copolymer and Controlled Release in Drug Delivery System[J].Liaoning Chemical Industry,2010,39(8):824-826. | |
| Authors: | MENG Li-shan CHEN Jin-li YAO Xin-jian |
| Affiliation: | 1. Department of Chemistry, Zhoukou Normal University, Zhoukou 466001, China ; 2. Zhoukou Safety Producing Train Centre , Zhoukou 466000,China; Zhoukou Hydrographic and Water Resources Survey Bureau, Zhoukou 466000, China) |
| Abstract: | In aqueous solution,amphiphilic block copolymer can form micelle with hydrophobic block as nuclear and hydrophilic block as shell by self-assembly.As hydrophilic block of copolymer can make the polymer micelle stability and also has a function of protec-tion,its applications in drug delivery systems can realize the controlled release of drugs.In this paper,some basic ways of block copoly-mer micellization were introduced,such as electrostatic interaction,changing temperature and pH,free radical copolymerization and so on.Further more,controlled release of drug by using amphiphilic block copolymers was discussed. |
| Keywords: | Amphiphilicity Micelle Controlled release |
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