A challenge towards next-generation research infrastructure for advanced life science

Recently, life scientists have expressed a strong need for computational power sufficient to complete their analyses within a realistic time as well as for a computational power capable of seamlessly retrieving biological data of interest from multiple and diverse bio-related databases for their research infrastructure. This need implies that life science strongly requires the benefits of advanced IT. In Japan, the Biogrid project has been promoted since 2002 toward the establishment of a next-generation research infrastructure for advanced life science. In this paper, the Biogrid strategy toward these ends is detailed along with the role and mission imposed on the Biogrid project. In addition, we present the current status of the development of the project as well as the future issues to be tackled. Haruki Nakamura, Ph.D.: He is Professor of Protein Informatics at Institute for Protein Research, Osaka University. He received his B.S., M.A. and Ph.D. from the University of Tokyo in 1975, 1977 and 1980 respectively. His research field is Biophysics and Bioinformatics, and has so far developed several original algorithms in the computational analyses of protein electrostatic features and folding dynamics. He is also a head of PDBj (Protein Data Bank Japan) to manage and develop the protein structure database, collaborating with RCSB (Research Collaboratory for Structural Bioinformatics) in USA and MSD-EBI (Macromolecular Structure Database at the European Bioinformatics Institute) in EU. Susumu Date, Ph.D.: He is Assistant Professor of the Graduate School of Information Science and Technology, Osaka University. He received his B.E., M.E. and Ph.D. degrees from Osaka University in 1997, 2000 and 2002, respectively. His research field is computer science and his current research interests include application of Grid computing and related information technologies to life sciences. He is a member of IEEE CS and IPSJ. Hideo Matsuda, Ph.D.: He is Professor of the Department of Bioinformatic Engineering, the Graduate School of Information Science and Technology, Osaka University. He received his B.S., M.Eng. and Ph.D. degrees from Kobe University in 1982, 1984 and 1987 respectively. For M.Eng. and Ph.D. degrees, he majored in computer science. His research interests include computational analysis of genomic sequences. He has been involved in the FANTOM (Functional Annotation of Mouse) Project for the functional annotation of RIKEN mouse full-length cDNA sequences. He is a member of ISCB, IEEE CS and ACM. Shinji Shimojo, Ph.D.: He received M.E. and Ph.D. degrees from Osaka University in 1983 and 1986 respectively. He was an Assistant Professor with the Department of Information and Computer Sciences, Faculty of Engineering Science at Osaka University from 1986, and an Associate Professor with Computation Center from 1991 to 1998. During the period, he also worked as a visiting researcher at the University of California, Irvine for a year. He has been Professor with Cybermedia Center (then Computation Center) at Osaka University since 1998. His current research work focus on a wide variety of multimedia applications, peer-to-peer communication networks, ubiquitous network systems and Grid technologies. He is a member of ACM, IEEE and IEICE.