| 常见蠕虫感染Th17细胞及IL-17细胞因子作用研究新进展 |
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| 引用本文： | 安然,郑宏.常见蠕虫感染Th17细胞及IL-17细胞因子作用研究新进展[J].中国病原生物学杂志,2012(5):396-400. |
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| 作者姓名： | 安然 郑宏 |
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| 作者单位： | 新疆医科大学第一附属医院麻醉科 |
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| 基金项目： | 国家自然科学基金项目(No.30960367) |
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| 摘 要： | 蠕虫感染在我国广泛流行,现阶段感染率有上升的趋势。蠕虫感染通过各种抗原及分泌物刺激机体产生免疫反应。Th17细胞是新发现的CD4+T细胞的亚群,其主要分泌IL-17。IL-17具有广泛的生物学效应,介导多种炎症因子及激活免疫反应。在蠕虫感染中,Th17及IL-17对宿主清除寄生虫及介导免疫病理反应起到了重要作用。本文综述了Th17及IL-17的调节机制及在常见蠕虫感染中Th17及IL-17的作用机制。
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| 关 键 词： | 蠕虫感染 Th17细胞 IL-17 免疫 综述 |
Advances in research on Th17 cells and IL-17 cytokines in common helminth infections |
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| AN Ran,ZHENG Hong.Advances in research on Th17 cells and IL-17 cytokines in common helminth infections[J].Journal of Pathogen Biology,2012(5):396-400. |
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| Authors: | AN Ran ZHENG Hong |
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| Affiliation: | (Department of Anesthesiology,the First Affiliated Hospital,Xinjiang Medical University,Urumqi 830054,China) |
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| Abstract: | Helminth infections are widespread in China,and their rates are increasing.The body is stimulated by a variety of antigens and secretions secreted by helminths.Th17 cells are a new found subset of CD4+ T cells and are a main source of IL-17.IL-17 has extensive biological action and can mediate diverse inflammation factors and activate the immune response.Th17 cells and IL-17 play a key role in helminth infections by removing parasites from the host’s body and mediating an immunopathological reaction.This paper reviews the regulatory mechanisms of Th17 and IL-17 in common helminth infections. |
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| Keywords: | Helminth Th17 cell IL-17 immunity review |
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