| 肉毒碱对兔在体缺血心室肌细胞动作电位的影响 |
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| 引用本文： | 赵志青,王若翔,吴博威,赵荣瑞.肉毒碱对兔在体缺血心室肌细胞动作电位的影响[J].药学学报,1985(7). |
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| 作者姓名： | 赵志青 王若翔 吴博威 赵荣瑞 |
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| 作者单位： | 山西医学院生理教研室 太原
(赵志青，王若翔，吴博威)，山西医学院生理教研室 太原(赵荣瑞) |
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| 摘 要： | 本实验观察了人工合成肉毒碱d,1-carnitine盐酸盐(VBt)对在位兔心急性心肌缺血早期左室肌细胞动作电位的影响。阻断冠脉引起动作电位振幅(APA)和零期最大除极速度(dv/dt)明显降低以及复极50%时程(APD_(50))和复极90%时程(APD_(90))明显缩短。VBt有延长心室肌细胞动作电位时程的作用(P<0.01),并能显著减轻缺血心肌细胞的APD_(50)和APD_(90)的缩短程度,但对APA和dv/dt的缺血性变化则无明显改善。
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| 关 键 词： | 肉毒碱 心肌动作电位 心肌缺血 |
EFFECTS OF CARNITINE(VBt)ON ACTION POTENTIALS OF RABBIT VENTRICULAR MUSCLE CELLS IN SITU DURING MYOCARDIAL ISCHEMIA |
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| ZHAO Zhi-Qing,WANG Ruo-Xiang,WU Bo-Wei and ZHAO Rong-Rui.EFFECTS OF CARNITINE(VBt)ON ACTION POTENTIALS OF RABBIT VENTRICULAR MUSCLE CELLS IN SITU DURING MYOCARDIAL ISCHEMIA[J].Acta Pharmaceutica Sinica,1985(7). |
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| Authors: | ZHAO Zhi-Qing WANG Ruo-Xiang WU Bo-Wei and ZHAO Rong-Rui |
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| Abstract: | This study was designed to evaluate whether VBt has beneficial effect on action potential of rabbit left ventricular muscle cells in situ during myocardial ischemia.Coronary occlusion resulted in significant diminution in amplitude of action potential (APA) and maximal depolarization rate of phase O (dv/dt), and decrease in action potential duration at 50% repolarization (APD_(50)) and 90% repolarization (APD_(90)). VBt lengthened the duration of action potential of ventricular muscle cell and greatly reduced the ischemic shortening changes of APD_(50) and APD_(90) (P<0.001), but exerted no significant effects on APA and dv/dt. These findings suggest that VBt may have some antiarrhythmic actions owing to its beneficial effect on APD_(50) during myocardial ischemia. |
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| Keywords: | Carnitine Action potential of myocardial cell Myocardial ischemia |
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