清热解毒口服液的絮凝澄清研究

目的：研究絮凝技术用于中药水提液精制的可行性与科学性。方法：采用絮凝技术与醇沉技术分别对清热解毒口服液处方的水提液进行精制，比较研究有效成分保留、鞣质的去除、生产周期及成本的考察。结果：絮凝技术制备的清热解毒口服液与醇沉技术相比，成本低，生产周期短，对鞣质的去除较完全，稳定性优于醇沉法，有效成分总黄酮的含量较醇沉制品略低，但明显高于药典标准；总多糖含量也略低于醇沉制品，TLC均能检出指标成分栀子甙和绿原酸。结论：絮凝技术可替代醇沉技术用于清热解毒口服液的澄清。

Purification of qingrejiedu oral liquid through flocculation

Objective To access feasibility of purification of herb extract liquid through flocculation. Methods Flocculation and precipitation were used to purify `qingrejiedu' oral liquid.Several parameters such as active component leftover, deprivation of vegetable tannins, the duration and the cost of production were compared.Based on the comparison, the conclusion has been drawn on. Results Compared with precipitation, flocculation showed some advantages of lower cost, shorter cycle of production and higher deprivation rate of vegetable tannins and better reliability. The content of the active component, flavonoids, was lower in sample prepared through flocculation than through precipitation,but exceeded the requirements of the pharmacopoeia. Also the content of the active component, total polysaccharide, was lower in sample prepared through flocculation than through precipitation, but key components, such as geniposide and chlorogenic acid, could be detected by TLC. Conclusion Flocculation can replace precipitation to purify qingrejiedu oral liquid.