Longitudinal developmental trajectories do not follow cross-sectional age associations in hippocampal subfield and memory development |
| |
| Affiliation: | 1. Brain Imaging Centre, Research Centre for Natural Sciences, Eötvös Loránd Research Network (ELKH), Budapest, Hungary;2. Institute of Psychology, ELTE Eötvös Loránd University, Budapest, Hungary;3. Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany;4. Department of Psychology, University of Texas at Austin, TX, USA;5. Departments of Epidemiology and Biostatistics & Neurology and Ophthalmology, Michigan State University, MI, USA;6. Faculty of Life Sciences, Berlin School of Mind and Brain and Department of Psychology, Humboldt-Universität zu Berlin, Berlin, Germany;7. Charité – Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Insitute of Medical Psychology, Berlin, Germany;8. Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, USA;9. Department of Psychology, Goethe University Frankfurt, Frankfurt am Main, Germany |
| |
| Abstract: | Cross-sectional findings suggest that volumes of specific hippocampal subfields increase in middle childhood and early adolescence. In contrast, a small number of available longitudinal studies reported decreased volumes in most subfields over this age range. Further, it remains unknown whether structural changes in development are associated with corresponding gains in children’s memory. Here we report cross-sectional age differences in children’s hippocampal subfield volumes together with longitudinal developmental trajectories and their relationships with memory performance. In two waves, 109 participants aged 6–10 years (wave 1: MAge=7.25, wave 2: MAge=9.27) underwent high-resolution magnetic resonance imaging to assess hippocampal subfield volumes (imaging data available at both waves for 65 participants) and completed tasks assessing hippocampus dependent memory processes. We found that cross-sectional age-associations and longitudinal developmental trends in hippocampal subfield volumes were discrepant, both by subfields and in direction. Further, volumetric changes were largely unrelated to changes in memory, with the exception that increase in subiculum volume was associated with gains in spatial memory. Longitudinal and cross-sectional patterns of brain-cognition couplings were also discrepant. We discuss potential sources of these discrepancies. This study underscores that children’s structural brain development and its relationship to cognition cannot be inferred from cross-sectional age comparisons. |
| |
| Keywords: | Mnemonic discrimination Spatial memory Associative memory Pattern separation Hippocampus Subiculum |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
