| 尼莫唑的合成 |
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| 引用本文： | 于书海,杨建辉,张志伟.尼莫唑的合成[J].中国现代应用药学,2010(3):226-227. |
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| 作者姓名： | 于书海 杨建辉 张志伟 |
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| 作者单位： | 河南省人民医院,郑州450003 |
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| 摘 要： | 目的合成尼莫唑。方法以吗啉与氯乙醇反应,经羟基氯代,再在相转移催化剂存在下与4（5）-硝基咪唑缩合制得目标产物。结果产物经熔点测定、红外及核磁共振氢谱得到确认。结论该工艺路线方法简便,原料易得,适合工业化生产。
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| 关 键 词： | 尼莫唑 合成 相转移催化 |
Synthesis of Nimorazole |
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| YU Shuhai,YANG Jianhui,ZHANG Zhiwei.Synthesis of Nimorazole[J].The Chinese Journal of Modern Applied Pharmacy,2010(3):226-227. |
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| Authors: | YU Shuhai YANG Jianhui ZHANG Zhiwei |
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| Affiliation: | (Henan Provincial People＇s Hospital,Zhengzhou 450003,China) |
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| Abstract: | OBJECTIVE To synthesis nimorazole.METHODS Nimorazole was prepared by reaction of morpholine with 2-chloroethanol,via chlorination,and condensed with 4（5）-nitro-imidazole in the presence of phase-transfer catalyst.RESULTS The structure was identified by mp.,IR and 1H-NMR.CONCLUSION The process can be easily controlled and suitable for a scale production. |
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| Keywords: | nimorazole synthesis phase-transfer catalysis |
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