Occurrence and distribution of salsolinol-like compound, 1-acetyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (ADTIQ) in Parkinsonian brains |
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Authors: | Yulin Deng Yongqian Zhang Yujuan Li Shengyuan Xiao Dewei Song Hong Qing Qin Li Ali H Rajput |
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Affiliation: | (1) School of Life Science, Beijing Institute of Technology, Beijing, 100081, China;(2) Division of Neurology, College of Medicine, University of Saskatchewan, Saskatoon, SK, S7N5E4, Canada |
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Abstract: | Parkinson’s disease (PD) arises from the loss of dopaminergic neurons in the substantia nigra. 1-Methyl-4-phenyl-1, 2, 3,
6-tetrahydropyridine (MPTP) is well known to cause Parkinsonism in humans with neurotoxicity specific for dopaminergic neurons.
The experience with MPTP supports the hypothesis that endogenous or xenobiotic neurotoxins are involved in the pathogenesis
of PD in humans. In our study, 1-acetyl-6, 7-dihydroxy-1, 2, 3, 4-tetrahydro-isoquinoline (ADTIQ), a novel compound, was found
in frozen human brain tissues. The formation of ADTIQ was demonstrated using dopamine and methylglyoxal under physiological
conditions. Methylglyoxal is a by-product of glycolysis. ADTIQ and its precursors, dopamine and methylglyoxal, were detected
in different regions of frozen human brains such as the substantia nigra, caudate nucleus, putamen, frontal cortex, and the
cerebellum. A significant difference in ADTIQ levels between control and Parkinson’s patients was found; for instance, the
ADTIQ level in putamen of PD patients was 0.76 ± 0.27 nmol/g compared to 0.10 ± 0.01 nmol/g in control. Our results might
indicate that ADTIQ is possibly related to Parkinson’s disease. |
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