130株结核分枝杆菌药敏试验结果分析

目的 探讨结核分枝杆菌依赖抗结核药物的发生率及特点。方法 采用绝对浓度间接法对137株结核分枝杆菌（含7株非结核分枝杆菌）进行7种药物的敏感性试验，药物依赖判定：在含抗结核药物的培养基上生长旺盛程度和菌量，高浓度药物培养基≥低浓度药物培养基≥对照培养基。结果 130株结核分枝杆菌和7株非结核分枝杆菌共检出依赖菌12株（8．76％）。其中依赖异烟肼3株（2．19％），依赖利福平10株（7．3％），依赖链霉素3株（2．19％），同时依赖2种药物者4株（2．92％）。结论 药物依赖现象均发生自耐多药菌株，尚未发现非结核分枝杆菌及初始耐药菌药物依赖。

Analysis of Microbia sensutivity tests in 130 Mycobarterium tuberculosis strains

Objective To explore the characteristics of mycobacterium dependend antituberculous drug. Methods 137 strains of mycobacterium were tested for resistance by the absolute concentration method on Lowenstein Jensen medium. Dependent positive were the coloun that on higher concentration drug medium stronger than lower concentration than controls. Results 12(8.76%) of the 130 strains M. tuberculosis and 7 strains nontuberculous mycuberculous (NTM) were found dependent, in which strains dependend on INH, RFP and SM were 3(2.19%), 10(7.3%) and 3(2.19%) respectively, 4(2.92%) were dependend on two drugs. Conclusions Were NTM dependent, Not found all detected from multiple strains.