| 儿童慢性特发性血小板减少性紫癜T细胞亚群变化研究 |
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| 引用本文： | 蒋小梅,吴攀,郑敏翠,旷文勇,李婉丽,杨海霞,邓映,杨振.儿童慢性特发性血小板减少性紫癜T细胞亚群变化研究[J].中国当代医药,2011,18(36):80-81. |
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| 作者姓名： | 蒋小梅 吴攀 郑敏翠 旷文勇 李婉丽 杨海霞 邓映 杨振 |
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| 作者单位： | 1. 湖南省儿童医院血液内科,湖南长沙,410007
2. 中南大学湘雅医院肿瘤科,湖南长沙,410008 |
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| 摘 要： | 目的：探讨儿童慢性特发性血小板减少性紫癜（idiopathicthrombocytopenicpurpura,ITP）T细胞亚群变化的具体情况及临床意义。方法：采用流式细胞仪分别检测30例儿童慢性ITP患者和15例健康儿童（对照组）的外周血CD4＋/CD8＋比值、天然杀伤细胞（naturalkillercell,NK细胞）计数、调节性T细胞（Treg细胞）计数,比较两组之间的差异。结果：慢性ITP组与对照组比较,CD4＋/CD8＋比值,CD16＋CD56＋NK细胞数,CD4＋CD25＋细胞/CD4＋细胞比值均降低,P均〈0.05。结论：CD4＋、CD8＋T细胞亚群改变,NK细胞减少,Treg细胞减少与儿童慢性ITP的发病有关。
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| 关 键 词： | 特发性血小板减少性紫癜 儿童 慢性 T淋巴细胞亚群 |
The study of the changing of T-cell subsets in children with chronic idiopathic thrombocytopenic purpura |
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| Authors: | JIANG Xiaomei WU Pan ZHENG Mincui KUANG Wenyong LI Wanli YANG Haixia DENG Ying YANG Zhen |
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| Affiliation: | 1.Department of Hematology,Children’s Hospital of Hunan Province,Changsha 410007,China;2.Department of Oncology,Xiangya Hospital of Central South-University of Changsha in Hunan Province,Changsha 410008,China |
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| Abstract: | Objective： To study the changing of T-cell subsets and its clinical significance in children with chronic idiopathic thrombocytopenic purpura. Methods： Peripheral blood CD4＋/CDs＋ ratios, natural killer （NK） counts and regulatory T cells counts of 30 children with chronic ITP and 15 healthy children （control group） were determined respectively by flow cytometry, and their differences were compared between two groups. Results： Peripheral blood CD4＋/CD8＋ ratios, natural killer （NK） counts and regulatory T cells counts in Chronic ITP group all decreased compared with control group （P〈0.05）. Conclusion： Chronic ITP in children is related to the changing of CD4＋ and CD8＋ T cell subsets and the decrease of NK cells and regulatory T cells counts. |
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| Keywords: | Idiopathic thrombocytopenic purpura Children Chronic T lymphocyte subsets |
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