Genotypic distribution of hepatitis C virus in Uttarakhand期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Genotypic distribution of hepatitis C virus in Uttarakhand

Affiliation:	1. Dept. of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India;2. Dept. of Gastroenterology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India;1. Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India;2. Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India;3. Department of Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India;4. Department of ENT, Christian Medical College, Vellore, Tamil Nadu, India;5. Department of Gastroenterology, Christian Medical College, Vellore, Tamil Nadu, India;1. Department of Microbiology and Immunology, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman;2. Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India;3. Department of Medical Laboratories, College of Applied Medical Science, Qassim University, Buraydah, Saudi Arabia;4. Department of Family Medicine and Public Health, College of Medicine and Health Sciences, Sultan Qaboos University Hospital, Muscat, Oman;1. Department of Laboratory Medicine, Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, China;2. Department of Laboratory Medicine,Yantai Affiliated Hospital of Binzhou Medical College, Yantai, China

Abstract:	PurposeHepatitis C virus is a major cause of chronic hepatitis with seven known genotypes. Uttarakhand is a north Indian state in the Sub-Himalayan region where the genotypic distribution of HCV is largely unknown. This study was undertaken in order to assess the pattern of genotype and subtype and understand the risk factors leading to transmission of Hepatitis C virus in this understudied region.MethodsAnti-HCV reactive cases were selected for determination of the circulating genotypes. Viral RNA was confirmed by real-time PCR. Strains were amplified and sequenced using Sanger's methods. Phylogenetic tree was constructed to determine the genotype.ResultsGenotype 3 was found to be the predominant genotype majority being subtype 3a and 3b followed by genotype 1. Subtypes 3g and genotype 4a were also observed. Major risk factor found was parenteral injection therapy from unregistered medical practitioners for minor ailments.ConclusionsFindings of our study will help in tailoring management and prevention protocols for HCV for the people of this region.

Keywords:	Hepatitis C Virus Sequencing Epidemiology Risk factors Genotype Subtype
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